nravelling the etiology of chronic idiopathic axonal polyneuropathy - Etiology of CIAP

niversitair Medisch Centrum Utrecht0 个研究点目标入组 948 人开始时间: 待定最近更新: 2024年5月13日

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•Inclusion criteria for patients with CIAP are: (1) patient age 45 years or older; (2) presence of distal symmetrical sensory or sensorimotor symptoms and deficits. These impairments should have begun distally in the legs, and have evolved slowly over months; (3) exclusion of any recognized cause of polyneuropathy such as diabetes mellitus, renal insufficiency, liver disease, alcohol abuse, medication, thyroid disease, vitamin deficiency, malignancy, polycythaemia, paraproteinaemia, systemic autoimmune or connective tissue disease, inflammatory bowel disease, metabolic storage disease, sarcoidosis, amyloidosis; (4) no indication of hereditary polyneuropathy; (5) electrophysiological investigations in agreement with axonal polyneuropathy without demyelinating features.
•Inclusion criteria for controls are: (1) age 45 years or older; (2) absence of symptoms suggestive of polyneuropathy; (3) absence of any recognized cause of polyneuropathy.

•Exclusion criteria for patients with CIAP are: (1) age younger than 45 years; (2) presence of asymmetrical or multifocal symptoms and deficits suggestive of a multifocal neuropathy; (3) (sub)acute onset and rapid progression of the neuropathy to a nadir within 12 weeks; (4) presence of any recognized of polyneuropathy, including hereditary neuropathy; (5) electrophysiological evidence of a demyelinating neuropathy according to established electrophysiological criteria.
•Exclusion criteria for controls are: (1) age younger than 45 years; (2) presence of symptoms suggestive of polyneuropathy; (3) presence of any recognized cause of polyneuropathy.

发起方

niversitair Medisch Centrum Utrecht