Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma

Completed

• Conditions: Pneumoconiosis; Silica; Silicosis

• Registration Number: NCT04205708
• Lead Sponsor: University of Oklahoma

Brief Summary

Silicosis, a preventable yet irreversible occupational lung disease, has an insidious onset with a latency period for diagnosis extending beyond 10 years from the initial exposure. The central hypothesis of this study is that silicosis cases may currently be going undetected. The long-term goal of this research is to determine the current prevalence and forecast the future prevalence of silicosis and other pneumoconiosis among working populations in Oklahoma and to assist the public health and the healthcare system in planning for a potential resurgence of silicosis.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-14
• Study First Submitted: 2019-11-19
• Study First Submitted QC: 2019-12-18
• Study First Posted: 2019-12-19
• Primary Completion: 2021-02-24
• Study Completion: 2022-06-10
• Status Verified: 2023-12
• Last Update Submitted: 2023-12-04
• Last Update Posted: 2023-12-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 183

Inclusion Criteria

• Male 30 years or older
• Past or present employment in dusty environment, exposed to dust at work
• Ability to consent and answer the questionnaire

Exclusion Criteria

• Female
• Never exposed to dusty environment or never exposed to dust at work
• Inability to consent and answer the questionnaire
• Age 29 years or younger

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Percentage of participants who report any exposure to silica	Single point assessment at baseline survey	Percentage of participants who report any exposure to silica
Prevalence of silicosis among study group	Single point assessment at clinic visit	Percentage of participants with confirmed diagnosis of silicosis
Estimate of average cumulative respirable crystalline silica exposure (semi-quantitative)	Single point assessment at baseline survey	Estimate of average cumulative respirable crystalline silica exposure (semi-quantitative)

Secondary Outcome Measures

Name	Time	Method
Analysis to determine if any demographic, work history, or other trait correlates with increased silica exposure	Single point assessment at baseline survey	Analysis to determine if any demographic, work history, or other trait correlates with increased silica exposure

Trial Locations

Locations (1)

University of Oklahoma Health Sciences Center; 🇺🇸 Oklahoma City, Oklahoma, United States