Eczema and dry skin – observational analysis of patients prescription patterns and healthcare utilizatio

Completed

• Conditions: Dry skin and/or eczema; Skin and Connective Tissue Diseases

• Registration Number: ISRCTN91126037
• Lead Sponsor: Johnson & Johnson Ltd

Brief Summary

1. 2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/30373584

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2014-12-31
• Study Start: 2017-07-19
• Last Update Posted: 19 November 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 1570

Inclusion Criteria

1. Patients with dry skin and/or eczema in 2008 and 2012
2. Exposed cohort: patients with at least 2 distinct emollient prescriptions within 6 months of index
3. Control cohort: patients with 2 healthcare exposures (visits or prescriptions) for dry skin and/or eczema in 6 months but no emollient prescriptions at any time
4. Continuous = 12 months of medical history prior to diagnosis (washout period) and = 24 months post dry skin and/or eczema diagnosis. The index date will be the date of dry skin and/or eczema diagnosis in those patients with at least 12 months washout period (i.e., first diagnosis in at least 12 months – this constitutes the clean” period)

Exclusion Criteria

1. Patients with concurrent skin diseases that are typically treated with topical corticosteroids (TCS) such as bullous pemphigoid, lupus, lichen planus, granuloma annulare, lichen sclerosis, alopecia areata and vitiligo
2. Patients with low-quality records or non-continuous data coverage
3. A diagnosis of dry skin-eczema during the washout period (12 months period prior to index diagnosis)

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measured using CPRD database over a two year period from initial diagnosis (post-index):<br>1. Health care utilisation:<br>1.1 Frequency of GP visits<br>1.2. Prescriptions for dry skin and eczema

Secondary Outcome Measures

Name	Time	Method
Measured using CPRD database over a two year period from initial diagnosis (post-index):<br>1. Percentage of patients treated with potent or very potent topical corticosteroids<br>2. Percentage of patients treated with antimicrobials and/or antibiotics