In Vitro Characterization and Enhancement of HIV-Specific CD8+ T Cells

Withdrawn

• Conditions: AIDS; HIV infection; 10047438

• Registration Number: NL-OMON42584
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 396

Inclusion Criteria

Age >18 years
Confirmed HIV-1 infection
Treatment or viral loads that fit into one of the study groups

Exclusion Criteria

Inability to donate 50 ml of blood
Pregnancy or breastfeeding
Major comorbidities

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>This is a discovery study aiming to study exhaustion in HIV-specific CD8+ T<br /><br>cells and how these functional defects can be modified by epigenetic<br /><br>inhibitors. The main study parameters are a) phenotypic and functional<br /><br>characterization of HIV- and CMV-specific CD8+ T cells from HIV-infected<br /><br>individuals; b) Increase of function and reverse of exhaustion phenotype by<br /><br>epigenetic inhibitors; c) Expression pattern of select post-transcriptional<br /><br>modifiers in HIV- and CMV-specific CD8+ T cells from HIV-infected individuals. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Non applicable</p><br>