Comparison of effectiveness between the oral administration and topical application of collagen on the reduction of skin wrinkles and roughness

Phase 1

Completed

• Conditions: Skin wrinkles and roughness on face; Oral of collagen, Topical application of collagen, Collagen cosmetic

• Registration Number: TCTR20210316015
• Lead Sponsor: /A

Brief Summary

Oral administration and topical application of collagen, both groups were unable to reduce wrinkles and skin roughness, but it can help increase elasticity, moisture and reduce transepidermal water loss. In all parameters, it was found that the two groups showed no difference in effectiveness.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-03-16
• Study Completion: 2021-05-15
• Results First Posted: 2022-08-17
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 65

Inclusion Criteria

1. Not menopause
2. Sign in to the consent form to participate in the study
3. No history of allergy to fish food
4. Not a skin disease or Allergic rash at the area to be tested
5. There are no contraindications or restrictions on the intake of protein as indicated by the doctor.
6. Do not take other protein supplements or drugs that can affect the skin condition, such as roaccutane, tranxenamic acid, d-penicillamine. During the trial
7. Not received any treatment for the face including Dermabrasion, Iontophoresis, radiofrequency (RF) in a period of 1 month prior to participation.
8. Not received Botulinum toxin injection at the site to be tested within 8 months prior to participation.
9. Not received filler in the area to be tested within 1 year prior to participating
10. Not smoking
11. Lifestyle do not exposed to heat and sunlight for many hours without protection
12. Not pregnant or breastfeeding

Exclusion Criteria

1. Want to leave research or have reasons to leave research
2. Pregnant during the study
3. Experiencing side effects or allergic reactions During the research
4. Forget to take collagen from 3 sachets per 4 weeks
5. More than 5 grams of skin product left per 4 weeks
6. Received any treatment for the face including injected with Botulinum toxin, Filler, laser during the research
7. There was a change in skin care and health behavior from the original during research
8. Appearance severe allergic rashes in the examination area

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
skin wrinkles and roughness at week 0 before experimental and week 4,8 after end of the intervention(VisioscanVC98) and at week 4,8 after end of the intervention(SQ), (SEQ)and Photograph Medical devices (VisioscanVC98), Satisfaction questionnaire(SQ), Side effects questionnaire(SEQ) and Photograph (iphone11)

Secondary Outcome Measures

Name	Time	Method
elasticity, moisture, water loss of the skin layers, evaluate side effects of using oral and topical collagen at week 0 before experimental and week 4,8 after end of the intervention(Cutometer dual MPA580 : Cutometer, Corneometer, TEWA) and at week 4,8 after end of the intervention(SQ), (SEQ)and Photograph Medical devices (Cutometer dual MPA580 : Cutometer, Corneometer, TEWA), Satisfaction questionnaire(SQ), Side effects questionnaire(SEQ) and Photograph (iphone11)