A study to compare the effects on laryngotracheal morbidity of air, 2 percent alkalinized lignocaine and dexamethasone used for endotracheal tube cuff inflation, a randomized control trial.
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 165
- 试验地点
- 1
- 主要终点
- sore throat incidence/severity
研究概览
简要总结
Endotracheal intubation often causes several postoperative laryngotracheal morbidities like sore throat, cough, dysphagia, hoarseness of voice. Different medications and techniques have been adopted to relieve these complications. Injecting alkalinized lignocaine into endotracheal tube cuff has already shown promising results in various studies. Injection Ketamine used intracuff also gave comparable results, but studies on intracuff dexamethasone are very few. Dexamethasone is a potent corticosteroid with analgesic, anti-inflammatory, and antiemetic properties. Preoperative IV dexamethasone has been reported to reduce the incidence of postoperative pain and swelling following oral surgeries. Even when used intracuff, dexamethasone yielded favorable results in the few studies that we have come across. Therefore, we wish study the effects of injection Dexamethasone against 2% alkalinized Lignocaine when used as an intracuff reservoir in relieving laryngotracheal morbidities.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)(—)
- 性别
- All
入选标准
- •age 18 to 60 years, ASA 1 and 2 undergoing elective surgery under general anaesthesia, patient given written informed consent.
排除标准
- •Duration of surgery 2 to 4 hrs, difficult airway requiring more than 2 trials of intubation, history of sore throat, allergies, bronchial asthma, chronic obstructive pulmonary disease, upper respiratory tract infections.
结局指标
主要结局
sore throat incidence/severity
时间窗: 1 hr,12 hr,24 hr post extubation
次要结局
- hoarseness of voice(1 hr,12 hr,24 hr post extubation)
- PONV(1 hr,12 hr,24 hr post extubation)
- cough(1 hr,12 hr,24 hr post extubation)
- dysphagia(1 hr,12 hr,24 hr post extubation)
研究者
Subhrajyoti Das
Institute of Postgraduate Medical Education and Research
