A randomized, double-blind, comparative study of preoperative magnesium sulphate versus zinc sulphate gargle for prevention of postoperative sore throat following endotracheal intubation
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Sore throat
研究概览
简要总结
Primary purpose: Post operative sore throat is a common undesirable consequence of tracheal intubation. The primary purpose of my protocol is to reduce the incidence of post operative sore throat by means of providing pre operative gargle with either magnesium sulphate or zinc sulphate gargle.
Postoperative sore throat remains a significant issue, with 20-74% of patients still suffering, despite the availability of pharmacological and non-pharmacological agents. Our goal as anaesthesiologists is to prevent this problem efficiently and cost-effectively.
Hypothesis: For this study null hypothesis is that there is no significant difference in the incidence of post operative sore throat with magnesium sulphate and zinc sulphate gargle.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •American society of anaesthesiologists (ASA) physical status I & II.
- •Patients undergoing elective surgeries under general anaesthesia with endotracheal intubation.
- •Those willing to participate in the study.
排除标准
- •Age more than 60 or less than 18 years.
- •Patients having chronic cough, sore throat preoperatively and allergy to the study drug.
- •Patient of ASA grade 3 and above.
- •Pregnant females.
- •Patient with surgeries around airway Patients with anticipated difficult intubation or with risk of aspiration of gastric contents.
结局指标
主要结局
Sore throat
时间窗: Time after extubation at start, then at 2, 4, 6, 12 and 24 hours.
次要结局
- Hemodynamic changes- HR, SBP, DBP, MAP(Time since induction of anaesthesia , intraoperatively at the interval of every 15 minutes & after extubation at start, then at 2, 4, 6, 12 & 24 hours.)
研究者
Dr Patrick Laldinliana
Vilasrao Deshmukh Government Medical College