Automitochondrial Transplantation Improves Live Birth in Elderly Patients With Low Prognosis After Repeated IVF Failure
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Infertility, Female
- Sponsor
- Peking University People's Hospital
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- live birth rate
- Status
- Enrolling By Invitation
- Last Updated
- 2 years ago
Overview
Brief Summary
The goal to this clinical trial is to study the effectiveness and safety of automitochondrial transplantation of urine derived stem cells(USCs) in in elderly patients with low prognosis after repeated IVF failure. The main questions it aims to answer are:
(1）test the effectiveness and safety of automitochondrial transplantation of urine derived stem cells (2) establish intracytoplasmic sperm injection(ICSI) mitochondrial transplantation platform Participants will be asked to:1)urine collections to further culture of autologous USCs 2)ovarian stimulation、trigger eggs、ICSI with autologous mitochondria 3）embryo transfer 4)accept pregnancy follow-up at given point
Investigators
Han Hongjing
chief physician
Peking University People's Hospital
Eligibility Criteria
Inclusion Criteria
- •At least 35 years old
- •Repeated IVF failure: more than or equal to 2 egg retrieval with poor embryo quality, no transplanted embryos or failed embryo transfer (more than or equal to 4 embryos)
- •Egg number ≤9
- •Participate voluntarily and sign informed consent.
Exclusion Criteria
- •1: Infertility caused by severe oligospermia, severe intrauterine adhesions, genital tract malformations, thyroid dysfunction and other endocrine, immune system, tumor and genetic diseases
Outcomes
Primary Outcomes
live birth rate
Time Frame: 1year after embryo transfer
Live birth rate per embryo transfer cycle (defined as live delivery after ≧28 weeks)