Routine Transcervical Thymectomy in MEN-1 Patients

Completed

• Conditions: Multiple Endocrine Neoplasia Type 1 (MEN-1); Thymic Carcinoid
• Interventions: Procedure: Routine thymectomy, which has been performed

• Registration Number: NCT05061784
• Lead Sponsor: National University Health System, Singapore

Brief Summary

A case series was built after review of available literature by searching four databases (PubMed, Embase, Medline and Cochrane Library) for observational studies or case reports on routine prophylactic TCT for MEN-1 and the development of thymic carcinoids.

Detailed Description

Introduction and Importance Malignant thymic carcinoids are uncommon but important entities among patients with multiple endocrine neoplasia type 1 (MEN-1). Current treatment guidelines advise the performance of a routine transcervical thymectomy (TCT) during parathyroidectomy, to prevent its development, although data on the yield of this prophylactic TCT is scarce. We aimed to revisit available literature to investigate and summarize the efficacy of routine TCT during neck exploration for parathyroidectomy, for the prevention of thymic carcinoid tumours among MEN-1 patients.

Methods A case series was built after review of available literature by searching four databases (PubMed, Embase, Medline and Cochrane Library) for observational studies or case reports on routine prophylactic TCT for MEN-1 and the development of thymic carcinoids.

Study Timeline

• Study Start: 2021-07-14
• Primary Completion: 2021-08-20
• Study Completion: 2021-08-20
• Status Verified: 2021-09
• Study First Submitted: 2021-09-02
• Study First Submitted QC: 2021-09-25
• Last Update Submitted: 2021-09-25
• Study First Posted: 2021-09-30
• Last Update Posted: 2021-09-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

• Studies including MEN-1 patients who underwent a routine thymectomy during parathyoidectomy

  • We accepted randomized controlled trials or observational studies that included patients of any age who underwent a routine TCT in the setting for MEN-1, published as full-length articles in peer-reviewed journals, which mentioned data on thymic carcinoid tumours.

Exclusion Criteria

• We excluded reviews, letters, conference proceedings and non-English publications.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
MEN-1 patients who underwent routine thymectomy during parathyroidecotmy	Routine thymectomy, which has been performed	A case series was built after review of available literature by searching four databases (PubMed, Embase, Medline and Cochrane Library) for observational studies or case reports on routine prophylactic TCT for MEN-1 and the development of thymic carcinoids.

Primary Outcome Measures

Name	Time	Method
Incidence of thyme carcinoid	The timeframe will be from date of transcervical thymectomy until the date of documented diagnosis of diagnosis of thymic NET; progression of disease or date of death from any cause, whichever came first, assessed up to 100 months.	Retrospective review of published studies

Trial Locations

Locations (1)

National University Hospital; 🇸🇬 Singapore, Singapore