Evaluation of the prevalence, incidence and progression of bone erosions in rheumatoid arthritis (RA) by high-resolution peripheral quantitative computer tomography (HRpQCT) compared to standard imaging techniques
Completed
- Conditions
- RA, HR-pQCT, MRI, US, RX, bone erosions
- Registration Number
- NL-OMON22023
- Lead Sponsor
- Maastricht University Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
4.2Inclusion criteria
In order to be eligible to participate in this study, a subject must meet all of the following criteria:
Exclusion Criteria
A subject who meets any of the following criteria will be excluded from participation in this study:
1.Patients who underwent surgery of the hand or fingers or who are expected to need surgery of the hand in due course
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome of the study is 1/ cross-sectionally - the prevalence of bone erosions and 2/ longitudinally - the progression of bone erosions in the 2nd and 3rd proximal interphalangeal (PIP) joints and metacarpophalangeal (MCP) joints of the hands bilaterally in patients with RA. In healthy controls only the dominant hand will be scanned and includes also the 2nd and 3rd distal interphalangeal (DIP) joints ,using the HRpQCT (800 RA joints + 480 healthy control joints in the total study).
- Secondary Outcome Measures
Name Time Method Secondary outcomes are the comparison of the number of joints with erosions detected by HRpQCT with 1/ the number of joints with erosions detected by X-rays, MRI and US and 2/ the number of joints with osteitis by MRI; exploring possibilities to quantify the 3-D joint space volume occupied by cartilage; and the correlation between the prevalence and progression of erosions with serum bone turnover markers.