Assessment of prevalence and characterization of osteoarthritis in four Gravets and Gangawata Korale in the Kandy district and a randomized control trial to assess the effectivity of embolization of genicular artery vs standard care to relieve pain in Kellgren-Lawrnce grade 3 & 4 osteoarthritis among patients attending the rheumatology clinic at Teaching Hospital Peradeniya
- Conditions
- Osteoarthritis
- Registration Number
- SLCTR/2024/001
- Lead Sponsor
- Faculty of Medicine, University of Peradeniya
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- Not specified
•Males and females with an age above 30 years
•Kelgren-Lawrence (KL) radiographic grading system- grade 3 and 4 knee osteoarthritis
•Primary knee OA
•Knee pain (>6 on visual analog scale) on at least half of the days in the preceding month at the time of inclusion
•Registered patient in rheumatology clinic with at least 6 months of standard medical treatments
•Individual without the mental capacity to consent
•Pregnant or lactating individuals
•Secondary osteoarthritis (due to inflammatory arthritis)
•Contraindication for angiography (ex: coagulopathy, renal insufficiency, contrast allergy)
•Previous surgical treatments for knee OA (eg: high tibial osteotomy) excluding knee arthroscopy.
•Musculoskeletal comorbidity (e.g: Rheumatoid arthritis or gout) potentially masking the effect of GAE.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement in pain as described by the Visual Analog Scale (VAS) [ Baseline, 1 month, 3 months, 6 months and 1 year]<br>
- Secondary Outcome Measures
Name Time Method Western Ontario and McMaster Universities Arthritis Index (WOMAC) functional status assessment. This is used in the evaluation of Hip and Knee Osteoarthritis. It is a questionnaire consisting of 24 items divided into 3 subscales: pain, stiffness and physical function of the subject.<br> [Baseline, 1 month, 3 months, 6 months and 1 year]<br>Muscle strength as measured by the Medical Research Council (MRC) scale of Quadriceps and Hamstring muscle. [Baseline, 1 month, 3 months, 6 months and 1 year]<br>Joint range-of-motion as assessed by the goniometer around the knee. <br> [Baseline, 1 month, 3 months, 6 months and 1 year]<br>Quality of life as measured by the Short form health survey (SF-36) questionnaire<br> [Baseline, 1 month, 3 months, 6 months and 1 year]<br>