Prediction and prevention of preeclampsia, intrauterine growth restriction, prenatal stress and fetal programming of child's psychological development

Academy of Finland (Finland)0 个研究点目标入组 1,000 人开始时间: 2007年9月6日最近更新: 2018年7月30日

适应症

试验速览

•Inclusion criteria (one of the following):
•1. Preeclampsia in a previous pregnancy
•2. IUGR in a previous pregnancy
•3. Essential hypertension
•4. Gestational diabetes in a previous pregnancy
•5. Diabetes mellitus type 1
•6. Previous pregnancy with fetal demise (> 22 gestational weeks or over 500 g)
•7. Body Mass Index (BMI) greater than 30 kg/m^2 prior to pregnancy
•8. Age younger than 20 or older than 40 years at the day of admission
•9. Systemic Lupus Erythematosus (SLE)
•10. Sjögren's syndrome
•Definitions for inclusion criteria:
•1. Preeclampsia is defined as de novo hypertension and proteinuria. Proteinuria is defined as presence of 0.3 g/day or more of protein in a 24-hour urine specimen
•2. IUGR is defined as birth weight below -2 standard deviations below mean for sex and gestational age according to Finnish standards
•3. Essential hypertension is defined as systolic blood pressure 140 mmHg or more and diastolic blood pressure 90 mmHg or more before 20th gestational week or medication for blood pressure
•4. Gestational diabetes is defined by one or more abnormal values in two-hour oral glucose tolerance test
•Subjects invited to participate in the study will be given written and oral information about the study. Each participant will sign an informed consent.

•1. Asthma (diagnosed by a physician)
•2. Allergy to ASA
•3. Tobacco smoking (during pregnancy)
•4. Previous peptic ulcer
•5. Previous placental ablation
•6. Inflammatory bowel diseases (Crohn´s disease, colitis ulcerosa)
•7. Rheumatoid arthritis
•8. Hemophilia or trombophilia (previous venous or pulmonary thrombosis and/or coagulation abnormality)
•9. Gestational weeks less than 12th more than 14th
•10. Multiple pregnancy

发起方