Comparison of Free-breathing 3D Quantitative Perfusion in Patients With MINOCA, Tako-Tsubo, SCAD, Myocarditis and NSTEMI in the Acute Phase and Post Convalescence
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 75
- 试验地点
- 2
- 主要终点
- Myocardial perfusion reserve index
研究概览
简要总结
This clinical study examines patients presenting with acute myocardial infarction and no significant coronary artery disease on coronary angiography (MINOCA) and patients with MINOCA-mimics with advanced CMR.
The present study aims to:
- assess the microvascular function with a novel quantitative 3D myocardial perfusion imaging approach in the acute phase and post-convalescence
- refine the role and diagnostic potential of advanced quantitative CMR imaging
- assess the potential prognostic significance of microvascular dysfunction and epicardial adipose tissue on cardiovascular outcomes
Participants will undergo advanced CMR imaging in the acute setting (within 10 days after event) and post convalescence (after 3 months).
详细描述
Advanced CMR includes a novel free-breathing motion-informed locally low-rank quantitative 3D myocardial perfusion imaging. Perfusion imaging will be compared with 3D late gadolinium enhancement (LGE) imaging. A cine Dixon sequence is performed for the assessment of epicardial adipose tissue (EAT).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •acute presentation with signs/symptoms of acute coronary syndrome or myocarditis
- •elevated cardiac biomarkers
- •no signficant coronary artery disease on coronary angiogram or coronary CT
排除标准
- •pacemaker/other devices or claustrophobia
- •severe asthma, chronic obstructive lung or kidney disease
- •acute pulmonary embolism
- •arrhythmia on ECG
- •moderate to severe valvular disease
研究组 & 干预措施
MINOCA
Patients with myocardial infarction with non-obstructive coronary artery disease (MINOCA) prospectively investigated with advanced CMR
干预措施: CMR (Diagnostic Test)
Myocarditis
Patients with suspected myocarditis prospectively investigated with advanced CMR
干预措施: CMR (Diagnostic Test)
Takotsubo cardiomyopathy
Patients with suspected Takotsubo cardiomyopathy prospectively investigated with advanced CMR
干预措施: CMR (Diagnostic Test)
Spontaneous coronary artery dissection (SCAD)
Patients with suspected/diagnosed spontaneous coronary artery dissection prospectively investigated with advanced CMR
干预措施: CMR (Diagnostic Test)
NSTEMI
Patients with confirmed non-ST elevation myocardial infarction on coronary angiography prospectively investigated with advanced CMR
干预措施: CMR (Diagnostic Test)
结局指标
主要结局
Myocardial perfusion reserve index
时间窗: within 10 days and after 3 months after index event
comparison of microvascular function in the acute phase versus post convalescence
次要结局
- epicardial adipose tissue (EAT)(4 months (measured either at first or second CMR))
- cardiovascular events(5 years)