Endothelial Dysfunction in Subjects With History of Premature Coronary Artery Disease

Phase 4

• Conditions: Coronary Heart Disease
• Interventions: Drug: Atorvastatin

• Registration Number: NCT00917527
• Lead Sponsor: Yonsei University

Brief Summary

The aim of this prospective study is to investigate the prevalence of endothelial dysfunction in subjects with family history of premature coronary heart disease. At the same time, the effect of atorvastatin in treating subclinical endothelial dysfunction in those patients will be evaluated.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-06
• Study First Submitted: 2009-06-09
• Study First Submitted QC: 2009-06-09
• Study First Posted: 2009-06-10
• Status Verified: 2012-07
• Last Update Submitted: 2012-07-20
• Last Update Posted: 2012-07-23
• Primary Completion: 2012-11
• Study Completion: 2013-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 77

Inclusion Criteria

• within 1 year
• the siblings of premature coronary heart disease(male<55years old, female<65years old: Framingham Heart Study)patients admitted relevant hospital

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Exclusion Criteria

• Documented coronary heart disease
• Any woman of childbearing potential who is pregnant, seeking to become pregnant or suspects that she may be pregnant.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Atorvastatin	Atorvastatin	-
Control	Atorvastatin	-

Primary Outcome Measures

Name	Time	Method
improvement of endothelial dysfunction with endo-PAT2000	6 weeks later drug administration

Trial Locations

Locations (1)

Severance Cardiovascular Hospital, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of