Randomized Placebo-controlled Crossover Trial of Endothelial Function Improvement in Subjects With History of Premature Coronary Artery Disease

Yonsei University1 site in 1 country77 target enrollmentJune 2009

ConditionsCoronary Heart Disease

InterventionsAtorvastatin

DrugsAtorvastatin

Overview

Phase: Phase 4
Intervention: Atorvastatin
Conditions: Coronary Heart Disease
Sponsor: Yonsei University
Enrollment: 77
Locations: 1
Primary Endpoint: improvement of endothelial dysfunction with endo-PAT2000
Last Updated: 13 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

The aim of this prospective study is to investigate the prevalence of endothelial dysfunction in subjects with family history of premature coronary heart disease. At the same time, the effect of atorvastatin in treating subclinical endothelial dysfunction in those patients will be evaluated.

Registry

clinicaltrials.gov

Start Date

June 2009

End Date

June 2013

Last Updated

13 years ago

Study Type

Interventional

Study Design

Crossover

Sex

All

Investigators

Sponsor

Yonsei University

Responsible Party

Principal Investigator

Hyuk-Jae Chang

Yonsei University

Eligibility Criteria

Inclusion Criteria

•within 1 year
•the siblings of premature coronary heart disease(male\<55years old, female\<65years old: Framingham Heart Study)patients admitted relevant hospital

Exclusion Criteria

•Documented coronary heart disease
•Any woman of childbearing potential who is pregnant, seeking to become pregnant or suspects that she may be pregnant.