Evaluation of Myocardial Function by Two Dimensional Speckle Tracking Echocardiography in Children With Duchenne Muscular Dystrophy Versus Healthy Children: a Comparative Transversal Multicenter Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 99
- Locations
- 2
- Primary Endpoint
- global longitudinal LV 2D strain
Study Overview
Brief Summary
Compare systolic function of left ventricle (LV) and right ventricle (VD) by 2D strain evaluation in Duchenne muscular dystrophy children versus a control group.
Detailed Description
Among the new echocardiographic techniques, two dimensional Speckle Tracking Imaging or "2D Strain" allows a dynamic study of regionalized and global ventricular contraction. With software for the spatial and temporal processing of a standard 2D image, this technique measures the displacement of natural markers present on the myocardial wall.
Used in adult cardiology since 2000, it could be eligible to pediatric population because of many potential applications. In Duchenne muscular dystrophy, myocardial disease leads to death in the third decade. Early diagnosis and preventive therapy remain a challenge. No clinic, biologic or radiologic markers can predict myocardial disease before advanced and irreversible heart failure.
Recent animals and human studies suggest that 2D strain anomalies could predict left ventricular systolic dysfunction in Duchenne muscular dystrophy. If it is confirmed, 2D strain could be used as early marker of myocardial disease in routine patient follow-up and in future therapeutic studies.
Purpose : - To compare systolic function of left ventricle (LV) and right ventricle (RV) by 2D strain evaluation in Duchenne muscular dystrophy children versus a control group.
- To correlate 2D Strain variables to conventional LV and RV echo variables.
- To evaluate 2D strain feasibility in normal children and Duchenne muscular myopathy population
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- — to 17 Years (Child)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Duchenne's muscular dystrophy (group 1) followed in our institution's referral center of neuromuscular diseases, during regular annual echocardiography follow-up.
- •Healthy children (group 2), addressed in pediatric cardiology
Exclusion Criteria
- Not provided
Arms & Interventions
dmd children
echocardiography
Intervention: speckle tracking (2D strain) echocardiography (Other)
healthy children
echocardiography
Intervention: speckle tracking (2D strain) echocardiography (Other)
Outcomes
Primary Outcomes
global longitudinal LV 2D strain
Time Frame: day 1
Secondary Outcomes
No secondary outcomes reported