2D Strain Evaluation: Children With Duchenne Muscular Dystrophy Versus Healthy Children

Not Applicable

Completed

• Conditions: Duchenne Muscular Dystrophy
• Interventions: Other: speckle tracking (2D strain) echocardiography

• Registration Number: NCT02418338
• Lead Sponsor: University Hospital, Montpellier

Brief Summary

Compare systolic function of left ventricle (LV) and right ventricle (VD) by 2D strain evaluation in Duchenne muscular dystrophy children versus a control group.

Detailed Description

Among the new echocardiographic techniques, two dimensional Speckle Tracking Imaging or "2D Strain" allows a dynamic study of regionalized and global ventricular contraction. With software for the spatial and temporal processing of a standard 2D image, this technique measures the displacement of natural markers present on the myocardial wall.

Used in adult cardiology since 2000, it could be eligible to pediatric population because of many potential applications. In Duchenne muscular dystrophy, myocardial disease leads to death in the third decade. Early diagnosis and preventive therapy remain a challenge. No clinic, biologic or radiologic markers can predict myocardial disease before advanced and irreversible heart failure.

Recent animals and human studies suggest that 2D strain anomalies could predict left ventricular systolic dysfunction in Duchenne muscular dystrophy. If it is confirmed, 2D strain could be used as early marker of myocardial disease in routine patient follow-up and in future therapeutic studies.

Purpose : - To compare systolic function of left ventricle (LV) and right ventricle (RV) by 2D strain evaluation in Duchenne muscular dystrophy children versus a control group.

* To correlate 2D Strain variables to conventional LV and RV echo variables.

* To evaluate 2D strain feasibility in normal children and Duchenne muscular myopathy population

Study Timeline

• Study Start: 2014-01
• Study First Submitted: 2015-04-13
• Study First Submitted QC: 2015-04-15
• Study First Posted: 2015-04-16
• Primary Completion: 2017-06
• Study Completion: 2017-06
• Status Verified: 2019-06
• Last Update Submitted: 2019-06-05
• Last Update Posted: 2019-06-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 99

Inclusion Criteria

• Duchenne's muscular dystrophy (group 1) followed in our institution's referral center of neuromuscular diseases, during regular annual echocardiography follow-up.
• Healthy children (group 2), addressed in pediatric cardiology

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
dmd children	speckle tracking (2D strain) echocardiography	echocardiography
healthy children	speckle tracking (2D strain) echocardiography	echocardiography

Primary Outcome Measures

Name	Time	Method
global longitudinal LV 2D strain	day 1

Trial Locations

Locations (1)

Pediatric and Congenital Cardiology and Pulmonology Department, Arnaud De Villeneuve University Hospital; 🇫🇷 Montpellier, France