Pain processing in patients after severe burns versus a population of unaffected volunteers: a compariso

Not Applicable

Recruiting

• Conditions: Pain processing in burns patients; Pain processing in healthy volunteers; Injuries and Accidents - Burns

• Registration Number: ACTRN12612001072808
• Lead Sponsor: Dr Alex Konstantatos

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-10-08
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Burns Group
1.Burns injury sustained approximately 6 months prior which was 10% or greater in total body surface area not affecting the area of testing (ankle and leg) bilaterally
2.Alert and orientated
3.Ability to give informed consent
4.Able to cooperate with the nerve stimulation test
5.No current pain at rest
Healthy Volunteer Group
1. Alert and orientated
2. Ability to give informed consent
3. Able to cooperate with the nerve stimulation test
4. Age average age of burns group +/- 5 years.

Exclusion Criteria

Burns Group
1.Patient Refusal
2.2.Burns/scarring to either of the two lower limbs below the knee
3.Inability to provide informed consent
4.Psychotic or paranoid disease
5.Chronic pain syndrome prior to burn
6.Acute/chronic brain syndrome
7.Current opioid therapy
8.History of untreated hypertension
9.History of diabetes
10.History of peripheral neuropathy

Health Volunteer group
1. Patient Refusal
2. Inabilility to provide informed consent
3. Current or past history of psychotic or paranoid disease
4. Past history of chronic pain sydrome(s)
5. Acute/chronic brain sydrome
6.Recent (within 2 weeks) or current opioid use
7.History of untreated hypertension
8.History of diabetes
9.History of peripheral neuropathy

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Amount of electrical stimulation (in miivolt) required to first produce a sensation of pain as produced by a single twitch according to known physiological testing algorithms for evaluation of threshold[6 months post burn injury];Amount of electrical stimulation (in miivolt) required to first produce a sensation of pain as produced by a single twitch according to known physiological testing algorithms for evaluation of threshold[once off visit after burns group complete on healthy volunteers]

Secondary Outcome Measures

Name	Time	Method
Measurement of wind up by specific patterns of stimulation using elctrophysiological testing (evaluating a pain threshold and applying 5 consecutive stimulations at 110% of the electrical threshold ) over a normal area of skin at a similar dermatomal level as a previous burns injury[At 6 month post burn injury];Measurement of wind up by specific patterns of stimulation using elctrophysiological testing (evaluating a pain threshold and applying 5 consecutive stimulations at 110% of the electrical threshold ) over a normal area of skin at a similar dermatomal level as a previous burns injury[once off visit after burns group complete on healthy volunteers];demographic data is collected using a survey[At 6 month post burn injury visit, once off visit for healthy volunteers.]