Clinical Decision Support for Atrial Fibrillation and Flutter

Active, not recruiting

• Conditions: Atrial Fibrillation and Flutter

• Registration Number: NCT05009225
• Lead Sponsor: Kaiser Permanente

Brief Summary

Atrial fibrillation (AF) is a major public health problem: it impairs quality of life and independently heightens the risks of ischemic stroke, heart failure and all-cause mortality. AF is a common reason for presenting to emergency departments (ED) in Kaiser Permanente Northern California (KPNC) and is associated with frequent hospitalization. Additionally, inter-facility hospitalization rates for AF vary across KPNC. Improvements in modifiable components of ED AF care could potentially reduce low-yield hospitalizations and the associated costs, patient inconveniences, and complications that can ensue. Real-time clinical decision support systems (CDSS) can transform entrenched physician practices and improve patient outcomes. The investigators will conduct a stepped-wedge cluster randomized trial of a CDSS intervention across 13 KPNC EDs for the comprehensive management of acute AF with the following three aims: 1) To evaluate the impact of the CDSS intervention on index hospitalization rates; 2) To evaluate the impact of the CDSS intervention on ED AF rate and rhythm control process-of-care metrics; and 3) To evaluate the impact of the CDSS intervention on AF stroke prevention actions for eligible participants at the time of ED discharge. The investigators hypothesize that the CDSS intervention will safely reduce index hospitalization rates, improve rate and rhythm control process-of-care metrics, and increase stroke prevention actions for eligible participants at ED discharge and within 30 days.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-08-10
• Study First Submitted QC: 2021-08-16
• Study First Posted: 2021-08-17
• Study Start: 2021-10-01
• Primary Completion: 2023-04-30
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-05
• Last Update Posted: 2024-03-06
• Study Completion: 2024-06-30

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 4000

Inclusion Criteria

• Adult (≥18y) KPNC members presenting to the ED with a primary ED diagnosis of atrial fibrillation/flutter (AF/FL). Subjects who meet criteria will be identified electronically within the CDSS tool in the electronic health record.

Exclusion Criteria

• Children (<18y).
• Non-members of KPNC.
• Patients who were prisoners, pregnant, receiving hospice or palliative care, or who left against medical advice at the index encounter for AF/FL.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of patients who received sustained rate-reduction medications	Through emergency department visit, an average of 8 hours
Number of patients who were hospitalized	Through emergency department visit, an average of 8 hours
Number of patients who received stroke prevention interventions	Through emergency department visit, an average of 8 hours

Trial Locations

Locations (16)

Kaiser Permanente Antioch Emergency Department; 🇺🇸 Antioch, California, United States

Kaiser Permanente Fremont Emergency Department; 🇺🇸 Fremont, California, United States

Kaiser Permanente Manteca Medical Center; 🇺🇸 Manteca, California, United States

Kaiser Permanente Modesto Medical Center; 🇺🇸 Modesto, California, United States

Kaiser Permanente Oakland Emergency Department; 🇺🇸 Oakland, California, United States

Kaiser Permanente Richmond Emergency Department; 🇺🇸 Richmond, California, United States

Kaiser Permanente Roseville Emergency Department; 🇺🇸 Roseville, California, United States

Kaiser Permanente South Sacramento Emergency Department; 🇺🇸 Sacramento, California, United States

Kaiser Permanente Sacramento Emergency Department; 🇺🇸 Sacramento, California, United States

Kaiser Permanente San Francisco Emergency Department; 🇺🇸 San Francisco, California, United States

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