Prevalence and Risk Factors of Insulin Resistance in Overweight and Obese Adolescents
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Assiut University
- Enrollment
- 50
- Primary Endpoint
- Number of participants of the Obese or Overweight category with elevated Serum Fasting Insulin and Serum Fasting glucose scores
Study Overview
Brief Summary
The aim of this study is to determine the prevalence of Insulin Resistance (IR) among overweight and obese adolescents using HOMA-IR scores and identify lifestyle risk factors in the IR and Non-IR group.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 10 Years to 18 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Adolescents of ages ≥ 10-≤18 years, of both sexes who are Overweight (BMI > 85th percentile) or Obese (BMI > 95th percentile).
Exclusion Criteria
- •Obesity due to Secondary causes as Cushing disease or hypothyroid patients, and any other patients with Chronic illness.
Outcomes
Primary Outcomes
Number of participants of the Obese or Overweight category with elevated Serum Fasting Insulin and Serum Fasting glucose scores
Time Frame: Baseline
Measuring Serum Fasting Insulin and Fasting Glucose levels to calculate HOMA-IR scores Insulin Resistance will be calculated using Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (Fasting Plasma Glucose (mmol/L) × Fasting Plasma Insulin (mU/L)/22.5) and defined as HOMA-IR ≥ 3.4 to Detect Prevalence of IR, higher scores indicating increased Insulin Resistance.
Secondary Outcomes
- Identifying Risk Factors for Insulin Resistance in each group(Baseline)
Investigators
Yara Mostafa
Pediatric Resident Physician
Assiut University