Quantification and Repeatability of Magnetic Stimulation
Not Applicable
Active, not recruiting
- Conditions
- Healthy
- Registration Number
- NCT05302752
- Lead Sponsor
- Swiss Federal Institute of Technology
- Brief Summary
In this project the quantification and the repeatability of responses to rapid bilateral magnetic stimulation of the phrenic nerves will be investigated in healthy humans.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 16
Inclusion Criteria
- healthy
- non-smoking
- normal lung function
- body mass index: 18.5-29.9 kg/m2
- able to communicate in english
- willing to adhere to study rules
Exclusion Criteria
- acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep
- intake of medications affecting metabolism, the cardiovascular, the neuromuscular or the respiratory system, or sleep
- any metal or electronics inside of the body
- presence of cardiac pacemaker, implanted defibrillators or implanted neurostimulators
- history of seizures or epilepsy
- tatoos on the stimulation sites
- previous enrolment in this study
- for women: pregnancy, breastfeeding, or intention to become pregnant during the study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Diaphragm contractility Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec Transdiaphragmatic pressure changes, i.e. changes in esophageal and gastric pressures, will be measured by a pressure transducer connected to balloon-catheters.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich
🇨🇭Zurich, ZH, Switzerland
Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich🇨🇭Zurich, ZH, Switzerland