Quantification and Repeatability of Magnetic Stimulation

Not Applicable

Active, not recruiting

• Conditions: Healthy
• Interventions: Other: Magnetic phrenic nerve stimulation

• Registration Number: NCT05302752
• Lead Sponsor: Swiss Federal Institute of Technology

Brief Summary

In this project the quantification and the repeatability of responses to rapid bilateral magnetic stimulation of the phrenic nerves will be investigated in healthy humans.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-03-18
• Study First Submitted QC: 2022-03-29
• Study First Posted: 2022-03-31
• Study Start: 2022-07-13
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-14
• Last Update Posted: 2025-05-18
• Primary Completion: 2026-12
• Study Completion: 2027-12

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• healthy
• non-smoking
• normal lung function
• body mass index: 18.5-29.9 kg/m2
• able to communicate in english
• willing to adhere to study rules

Exclusion Criteria

• acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep
• intake of medications affecting metabolism, the cardiovascular, the neuromuscular or the respiratory system, or sleep
• any metal or electronics inside of the body
• presence of cardiac pacemaker, implanted defibrillators or implanted neurostimulators
• history of seizures or epilepsy
• tatoos on the stimulation sites
• previous enrolment in this study
• for women: pregnancy, breastfeeding, or intention to become pregnant during the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Bilateral rapid magnetic stimulation of the phrenic nerves	Magnetic phrenic nerve stimulation	Each participant will be tested on three different days with optimal settings for bilateral rapid magnetic stimulation of the phrenic nerves established on visit 1 and then repeated on visits 2 and 3.

Primary Outcome Measures

Name	Time	Method
Diaphragm contractility	Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec	Transdiaphragmatic pressure changes, i.e. changes in esophageal and gastric pressures, will be measured by a pressure transducer connected to balloon-catheters.

Trial Locations

Locations (1)

Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich; 🇨🇭 Zurich, ZH, Switzerland