Assessment of Sarcopenia and Bone Mineral Density Relation in Hip Fracture Patients: A Cross-Sectional Study by Using STAR Value
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- Sonographic Thigh Adjustment Ratio (STAR) value
研究概览
简要总结
The study aims to investigate the relationship between sarcopenia and bone mineral density (BMD) in patients with hip fractures using sonographic thigh adjustment ratio (STAR) and dual-energy X-ray absorptiometry (DXA), as well as the relationship of sociodemographic factors, laboratory results, and comorbidities to these measurements.
Cross-sectional research was undertaken on patients with hip fractures in Kastamonu, Turkey. Sarcopenia was identified based on the ISarcoPRM algorithm, which utilizes poor grip strength (<22 kg for females and < 32 kg for males) along with low STAR values (< 1 for females and <1.4 for males). Sociodemographic data of the patients and levels of total protein, albumin, and 25-OH-vitamin D3 (25[OH]D) were obtained from all the patients. The BMD (bone mineral density) and T-scores of the proximal femur were measured using DXA (dual-energy X-ray absorptiometry).
详细描述
Introduction
Sarcopenia is a progressive and common skeletal muscle disorder, that causes progressive loss of age-related muscle strength and mass, associated with an increased likelihood of outcomes such as falls, fractures, physical disability, and death. Estimates place the overall prevalence of sarcopenia in older adults at approximately 10-40%. Osteoporosis and sarcopenia, prevalent conditions of advanced age, have comparable etiologies and risk factors. The co-occurrence of these illnesses amplifies the incidence of falls, fractures, and mortality. While EWGSOP2 and AWGS guidelines recommend using validated technologies like bioimpedance analysis, dual X-ray absorptiometry (DXA), computed tomography and magnetic resonance imaging for evaluating sarcopenia, these may not be feasible in certain clinical situations. The International Society of Physical and Rehabilitation Medicine (ISPRM) has suggested a different algorithm to diagnose sarcopenia by measuring anterior thigh muscle thickness using ultrasound (US). This method is easy to obtain, does not involve radiation, and is less expensive.
The study uses the sonographic thigh adjustment ratio (STAR) to look into the link between sarcopenia and bone mineral density (BMD) in people who have had a hip fracture. Additionally, the study explores the association between sociodemographic factors, laboratory results, comorbidities, and these measurements.
- Material and Method
2.1. Study Design and Population
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 58 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •the detection of low muscle strength with a hand dynamometer
- •scheduled for hip fracture surgery.
排除标准
- •terminal disease
- •acute or chronic neuromuscular disease
- •traumatic or pathological hip fracture.
结局指标
主要结局
Sonographic Thigh Adjustment Ratio (STAR) value
时间窗: baseline
The study used the standard sonographic thigh adjustment ratio values of 1.0 for female patients and 1.4 for male patients. These values are found by dividing the thickness of the anterior thigh muscle (in mm) by the person's body mass (in kg/m2).
Bone Mineral Density (g/cm2)
时间窗: baseline
Non-fracture proximal femur neck BMD (g/cm2) was obtained using the same DXA (Stratos DR (DMS), Mauguio, France)
T-scores
时间窗: baseline
A non-fracture proximal femur neck T score was obtained using the same DXA and is classified as normal if their T score exceeds -1 standard deviation (SD), as osteopenic if it falls between -2.5 SD and -1 SD, and as osteoporotic if it equals or falls below -2.5 SD.
次要结局
- Albumin levels(baseline)
- Protein levels(baseline)
- 25[OH]D levels(baseline)
研究者
Gamze Gul Gulec
DR
Kastamonu University