Sarcopenia, Fall and Osteoporosis in Patients With Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 140
- 试验地点
- 2
- 主要终点
- Difference in appendicular lean body mass
研究概览
简要总结
This study is a cross-sectional study that wishes to investigate whether there is an increased incidence of sarcopenia in patients with chronic kidney disease compared to the Danish background population. A possible association between sarcopenia and fall, as well as the incidence of osteoporosis in patients with chronic kidney disease will also be described.
详细描述
Sarcopenia is a condition diagnosed from different clinical findings such as low muscle mass, low muscle strength and possibly also poor physical performance. In the general population, the risk of fall and bone fracture increases, when sarcopenia is also present.
Sarcopenia is known to occur in patients with chronic kidney disease, but whether, and if so, how this differs from the incidence in patients without kidney disease has not previously been described.
Patients with chronic kidney disease have a 3 times higher risk of bone fracture compared to the Danish background population, and they also have an increased risk of falls.
The association between sarcopenia, risk of falls and osteoporosis in patients with kidney disease is until now sparsely described, and because of this, the investigators want to explore this further in this cross-sectional study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 120 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥20 years
- •Chronic kidney disease stage 4-5 not on dialysis (nonD) (corresponding to an estimated glomerular filtration rate (eGFR) ≤30 ml/min based on Kidney Disease Improving Global Outcomes (KDIGO) definition and not on dialysis)
排除标准
- •Kidney transplanted
- •Immobilized/hospitalized for more than 1 week within the last 6 weeks
- •Active treatment with growth hormone or sex hormone
- •Known muscle disease
- •The lack of ability to speak or understand Danish
- •The lack of ability to give an informed consent
- •The lack of ability to participate in a clinical study based on the assessment by the local investigator
结局指标
主要结局
Difference in appendicular lean body mass
时间窗: Day 0 (day of study procedure)
Difference in appendicular lean body mass between patients with chronic kidney disease and a healthy control group examined in a previous study
次要结局
- Difference in the incidence of sarcopenia(Day 0 (day of study procedure))
- Difference in appendicular muscle mass(Day 0 (day of study procedure))
- Difference in handgrip strength(Day 0 (day of study procedure))
- Difference in the incidence of osteoporosis(Day 0 (day of study procedure))
- Difference in gait speed(Day 0 (day of study procedure))
- Difference in sit-to-stand test(Day 0 (day of study procedure))
- Difference in the tendency to fall(Day 0 (day of study procedure))
- The correlation between total lean and appendicular lean body mass, handgrip strength, gait speed, sit-to-stand test, tendency to fall and osteoporosis(Day 0 (day of study procedure))
研究者
Ditte Hansen
Associate professor, MD, PhD
Herlev Hospital