The effect of Pilates exercise on the treatment of multiple sclerosis

Not Applicable

• Conditions: multiple sclerosis.; Multiple sclerosis

• Registration Number: IRCT20220324054348N1
• Lead Sponsor: The University of Hakim Sabzevari

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 30 May 2022

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 44

Inclusion Criteria

at least two years of history
EDSS between 2 and 5
no smoking,
no regular exercise

Exclusion Criteria

Muscle injuries
Severe relapse of the disease
disability to perform sports exercises
Lack of regular participation in the training protocol
Participate in a training program other than the research training protocol,
Pregnancy
relapse of MS in the last 12 weeks
Change in MS medication or steroid treatment in the last 12 weeks and period of practice
Lack of cooperation until the end of the research process

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood serum vitamin D status. Timepoint: 48 hours before and 48 hours after the intervention. Method of measurement: enzyme-linked immunosorbent assay (ELISA) by the Kit.;The inflammatory status of axonal damage (Neurofilament light chain). Timepoint: 2 days before the intervention and 2 days after the intervention. Method of measurement: enzyme-linked immunosorbent assay (ELISA) by the Kit.;Status of neuroprotective metabolites in the kynurenine pathway (kynurenine and kynurenic acid). Timepoint: 48 hours before and 48 hours after the intervention. Method of measurement: Liquid chromatography–mass spectrometry (LC–MS).;Status of neurodegenerative metabolite in the kynurenine pathway (quinolinic acid). Timepoint: 48 hours before and 48 hours after the intervention. Method of measurement: Liquid chromatography–mass spectrometry (LC–MS).

Secondary Outcome Measures

Name	Time	Method
Assess fatigue status. Timepoint: Before the intervention and 2 days after the intervention. Method of measurement: By the Fatigue Severity Scale (FSS) Questionnaire.;Evaluation of Quality of life. Timepoint: 48 hours before and 48 hours after the study. Method of measurement: By multiple sclerosis Quality of life-54 (MSQOL-54) Questionnaire.;Evaluation of deppresion. Timepoint: 48 hours before and 48 hours after the study. Method of measurement: questionnaires Depression, Anxiety, Stress Scales (DASS-21).;Physical function based on 6 minutes walking time. Timepoint: 48 hours before and 48 hours after the study. Method of measurement: Measurement of physical function (cardiorespiratory endurance) by 6-minute walking test.