Incidence and risk factors of viral infections in patients after liver transplantatio

• Conditions: Patients undergoing orthotopic liver transplantation from deceased donors; K74.6; C22.0; Other and unspecified cirrhosis of liver; Liver cell carcinoma

• Registration Number: DRKS00006754
• Lead Sponsor: Klinik für Anaesthesiologie Universitätsklinikum Heidelberg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-09-17
• Study Completion: 2016-03-14
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

• Liver transplantation at the center of transplantation in Heidelberg
• Written and signed informt consent
• Age > 18 years

Exclusion Criteria

Non-Compliance to the including criteria’s

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence and progress of viral infections in patients with liver transplantation. The determination of the initial viral findings and the course by using ELISA- and PCR-methods (Polymerase Chain Reaction) for HSV (herpes simplex virus) and CMV (Cytomegalovirus) detection from blood plasma. The effectiveness of an antiviral prophylaxis to prevent invasive viral infection will also be determined.

Secondary Outcome Measures

Name	Time	Method
Estimation of the validity of scoring systems (APACHE II, SOFA, MELD) and clinical laboratory parameters for the prognosis of viral infection in liver transplanted patients. Development of a scoring system to estimate the infection risk and to reduce the over-treatment. Evaluation of acetylcholinesterase and butyrilcholinesterase as new marker for synthesis performance of the new donor organ or as preterm infection parameter.