Cannabidiol in Youth Alcohol Use Disorder
- Registration Number
- NCT05317546
- Lead Sponsor
- Medical University of South Carolina
- Brief Summary
The goal of this study is to test cannabidiol (CBD) as a potentially effective candidate medication for youth alcohol use disorder (AUD). To accomplish this goal, this study will use a randomized, double-blind, within-subjects crossover design. In counterbalanced order, 50 youth (ages 16-22) will receive 600 mg of CBD or placebo three hours before a neuroimaging and behavioral assessment paradigm. The total amount of time the participant will be in the study is approximately one month.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 44
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Cannabidiol, Then Placebo Cannabidiol - Placebo, Then Cannabidiol Cannabidiol -
- Primary Outcome Measures
Name Time Method Glutamate Changes 3 hours after administration of 600mg CBD vs. placebo Glutamate level in the anterior cingulate cortex as measured by magnetic resonance spectroscopy
Alcohol cue reactivity neural activation Changes 3 hours after administration of 600mg CBD vs. placebo Blood oxygen level dependent (BOLD) signal during alcohol cue reactivity in reward and salience brain regions
Alcohol cue reactivity (lab-based paradigm) Changes 3 hours after administration of 600mg CBD vs. placebo In vivo response to olfactory alcohol cues measured via subjective ratings
GABA Changes 3 hours after administration of 600mg CBD vs. placebo GABA level in the anterior cingulate cortex as measured by magnetic resonance spectroscopy
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States