ACUTE GASTROINTESTINAL INJURY GRADE AS A PREDICTOR OF ALL CAUSE MORTALITY IN CRITICALLY ILL PATIENTS IN A TERTIARY CENTRE -A PROSPECTIVE OBSERVATIONAL STUDY
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 117
- 试验地点
- 1
- 主要终点
- To assess the correlation between Acute Gastrointestinal Injury grade and overall mortality in critically ill patients.
研究概览
简要总结
Introduction
Acute gastrointestinal injury (AGI) is a significant but often under-recognized issue in critically
ill patients, characterized by varying degrees of GI dysfunction, with a prevalence of 30% to
70%. The European Society of Intensive Care Medicine (ESICM) classifies AGI into four
grades based on severity, aiding in standardizing assessment and management. AGI’s
pathophysiology involves hypoperfusion, reperfusion injury, inflammation, and microbial
translocation, leading to increased morbidity and mortality. Higher AGI grades are strongly
associated with increased mortality. D-lactate, a bacterial fermentation byproduct, emerges as
a potential biomarker for diagnosing and prognosticating AGI, correlating with the severity of
GI dysfunction. Despite its clinical relevance, AGI remains under-diagnosed due to the lack of
standardized criteria. Further research is needed to validate AGI grading, identify additional
biomarkers, and establish standardized diagnostic and management protocols, thereby
improving patient outcomes in ICU settings.
This will be a prospective observational study conducted in the Department of Critical care
medicine, King George Medical University, Lucknow, Uttar Pradesh.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 90.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients will be included if they meet the following criteria Aged 18 years or older Admitted to the ICU and expected to stay for more than 48 hours Provide informed consent to participate in the study.
排除标准
- •Patients will be excluded if they have Pre-existing gastrointestinal conditions Undergone major abdominal surgery within the last six months Declined to participate in the study.
结局指标
主要结局
To assess the correlation between Acute Gastrointestinal Injury grade and overall mortality in critically ill patients.
时间窗: patients will be assessed at baseline and after discharged or death and will be follow up upto 30 days and 90 days
次要结局
- To identify the potential risk factors contributing to higher AGI grades & increased mortality in critically ill patients.(To evaluate the role of D lactate biomarkers in predicting the severity of AGI & its impact on mortality in critically ill patients.)
研究者
Suryavanshi Jha
King Georges Medical University Lucknow