Follow-up of morphologic and functional Lung Damage after severe COVID-19 Pneumonia
- Conditions
- Residual lung damage after COVID-19 pneumonia
- Registration Number
- DRKS00024511
- Lead Sponsor
- Klinik für Diagnostische und interventionelle RadiologieUniversitätsklinikum Heidelberg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting stopped after recruiting started
- Sex
- All
- Target Recruitment
- 13
Inclusion Criteria
a) Patients after severe course of and/or hospitalization for COVID-19 pneumonia
b) Patients presenting with lung function impairment developing after COVID-19 pneumonia c) Patients after COVID-19 pneumonia with clinical indications for imaging (typically CT)
Exclusion Criteria
a) missing informed consent
b) contra-indications for MRI (pacemakers, implants, claustrophobia)
c) contra-indications for the contrast material (renal dysfunction, prior adverse reactions) - in these cases the MRI protocol can be limited to the non-ce sequences.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the quality and prevalence of morphologic and functional lung damage after severe COVID-19 pneumonia over up to two years using lung MRI.
- Secondary Outcome Measures
Name Time Method 1. Establishment of MRI as radiation-free method for the follow-up after severe virus-pneumonia<br>2. Optimization of the MRI protocol for this purpose<br>3. Detection of appropriate imaging-based biomarkers (lung perfusion, lesion scores) and combinations with clinical biomarkers<br>4. To refine the procedures and to gain the necessary experience for the set-up a large multi center-trial, if needed