The Effect of Preoperative and Post Operative Misoprostol Administration on Intraoperative Blood Loss and Postpartum Hemorrhage in CS
Overview
- Phase
- Phase 4
- Intervention
- cesarean section
- Conditions
- Post Partum Hemorrhage
- Sponsor
- Cairo University
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- postpartum hemorrhage
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
• Patients will be divided into two groups 100 patients will receive routine ecbolics (for example oxytocin) after delivery of baby The 100 patients will receive routine ecbolics (for example oxytocin) after delivery of baby plus 400 microgram misoprostol rectally with catheterization and another 400 microgram rectally after closure of abdomen
Then we will compare between two groups regarding
- Intaoperative blood loss
- Risk of Postpartum hemorraghe in the first 24 hrs
- HB pre and postoperative for all patients
Intraoperative blood loss will be estimated by the number and weight of soaked towels and amount of blood in suction unit
Detailed Description
• Patients will be divided into two groups 100 patients will receive routine ecbolics (for example oxytocin) after delivery of baby The 100 patients will receive routine ecbolics (for example oxytocin) after delivery of baby plus 400 microgram misoprostol rectally with catheterization and another 400 microgram rectally after closure of abdomen Then we will compare between two groups regarding * Intaoperative blood loss * Risk of Postpartum hemorraghe in the first 24 hrs * HB pre and postoperative for all patients Intraoperative blood loss will be estimated by the number and weight of soaked towels and amount of blood in suction unit
Investigators
Ahmed M Maged, MD
professor
Cairo University
Eligibility Criteria
Inclusion Criteria
- •women attending for elective CS.
- •Age between 20-35 years.
- •Normal placental site
- •Normal coagulation profile
- •Full term pregnancies(above 37 wks)
- •Medically free
- •Spinal anesthesia
- •Living baby
- •Average liquor by U/S
Exclusion Criteria
- •• Women attending for emergency CS
- •.age below 20 or above 35
- •Abnormal placentation (Placenta previa,accrete,increta or percreta)
- •Women with coagulopathy
- •Preterm pregnancies (before 37 wks)
- •Medical disorder (Hypertension,Diabetes, Endocrinal disorder)
- •General anathesia
- •Oligo or polyhydraminos by U/S
Arms & Interventions
Routine ecbolic group
100 patients will receive routine ecbolics ( oxytocin) after delivery of baby
Intervention: cesarean section
Routine ecbolic group
100 patients will receive routine ecbolics ( oxytocin) after delivery of baby
Intervention: Oxytocin
Misoprostol group
The 100 patients will receive routine ecbolics (oxytocin) after delivery of baby plus 400 microgram misoprostol rectally with catheterization and another 400 microgram rectally after closure of abdomen
Intervention: cesarean section
Misoprostol group
The 100 patients will receive routine ecbolics (oxytocin) after delivery of baby plus 400 microgram misoprostol rectally with catheterization and another 400 microgram rectally after closure of abdomen
Intervention: Misoprostol
Misoprostol group
The 100 patients will receive routine ecbolics (oxytocin) after delivery of baby plus 400 microgram misoprostol rectally with catheterization and another 400 microgram rectally after closure of abdomen
Intervention: Oxytocin
Outcomes
Primary Outcomes
postpartum hemorrhage
Time Frame: 24 hours after cesarean section