The Effect of Preoperative and Post Operative Misoprostol Administration on Intraoperative Blood Loss and Postpartum Hemorrhage in CS
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- postpartum hemorrhage
研究概览
简要总结
• Patients will be divided into two groups 100 patients will receive routine ecbolics (for example oxytocin) after delivery of baby The 100 patients will receive routine ecbolics (for example oxytocin) after delivery of baby plus 400 microgram misoprostol rectally with catheterization and another 400 microgram rectally after closure of abdomen
Then we will compare between two groups regarding
- Intaoperative blood loss
- Risk of Postpartum hemorraghe in the first 24 hrs
- HB pre and postoperative for all patients
Intraoperative blood loss will be estimated by the number and weight of soaked towels and amount of blood in suction unit
详细描述
• Patients will be divided into two groups 100 patients will receive routine ecbolics (for example oxytocin) after delivery of baby The 100 patients will receive routine ecbolics (for example oxytocin) after delivery of baby plus 400 microgram misoprostol rectally with catheterization and another 400 microgram rectally after closure of abdomen
Then we will compare between two groups regarding
- Intaoperative blood loss
- Risk of Postpartum hemorraghe in the first 24 hrs
- HB pre and postoperative for all patients
Intraoperative blood loss will be estimated by the number and weight of soaked towels and amount of blood in suction unit
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •women attending for elective CS.
- •Age between 20-35 years.
- •Normal placental site
- •Normal coagulation profile
- •Full term pregnancies(above 37 wks)
- •Medically free
- •Spinal anesthesia
- •Living baby
- •Average liquor by U/S
排除标准
- •• Women attending for emergency CS
- •.age below 20 or above 35
- •Abnormal placentation (Placenta previa,accrete,increta or percreta)
- •Women with coagulopathy
- •Preterm pregnancies (before 37 wks)
- •Medical disorder (Hypertension,Diabetes, Endocrinal disorder)
- •General anathesia
- •Oligo or polyhydraminos by U/S
研究组 & 干预措施
Routine ecbolic group
100 patients will receive routine ecbolics ( oxytocin) after delivery of baby
干预措施: cesarean section (Procedure)
Routine ecbolic group
100 patients will receive routine ecbolics ( oxytocin) after delivery of baby
干预措施: Oxytocin (Drug)
Misoprostol group
The 100 patients will receive routine ecbolics (oxytocin) after delivery of baby plus 400 microgram misoprostol rectally with catheterization and another 400 microgram rectally after closure of abdomen
干预措施: cesarean section (Procedure)
Misoprostol group
The 100 patients will receive routine ecbolics (oxytocin) after delivery of baby plus 400 microgram misoprostol rectally with catheterization and another 400 microgram rectally after closure of abdomen
干预措施: Misoprostol (Drug)
Misoprostol group
The 100 patients will receive routine ecbolics (oxytocin) after delivery of baby plus 400 microgram misoprostol rectally with catheterization and another 400 microgram rectally after closure of abdomen
干预措施: Oxytocin (Drug)
结局指标
主要结局
postpartum hemorrhage
时间窗: 24 hours after cesarean section
次要结局
未报告次要终点
研究者
Ahmed M Maged, MD
professor
Cairo University