Evaluation of the Effect of Narrowband UVB Versus Methotrexate on Serum TWEAK Level in Psoriasis
- Registration Number
- NCT04811911
- Lead Sponsor
- Aswan University Hospital
- Brief Summary
The aim of the study is to evaluate the effect of NB-UVB versus MTX on serum TWEAK level in psoriatic patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 30
- Patients with moderate to severe plaque psoriasis of any age and gender.
- History of psoriasis treatment with systemic and biological agents prior to the study for at least 3 months.
- Pregnancy and lactation.
- Infections
- Patients with chronic diseases: hepatic disorders, hematologic disease, chronic renal failure or cancer
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Arm && Interventions
Group Intervention Description Narrowband ultraviolet B Narrowband ultraviolet B Patients will receive 8 sessions of NB-UVB per month for 3 successive months Methotrexate group Methotrexate Patients will receive 25 mg/1ml of methotrexate vial per week for 3 successive months
- Primary Outcome Measures
Name Time Method Serum TWEAK in psoriasis 3 months Measurement of tumor necrosis factor weak inducer of apoptosis (TWEAK) "pg/ml"; in psoriatic patients before and after treatment with NB-UVB versus MTX in comparison with healthy individuals, using ELISA (enzyme-linked immunosorbent assay).
- Secondary Outcome Measures
Name Time Method Treatment of psoriasis 3 months Clinical evaluation: Assessment of disease severity will be performed by using psoriasis area severity index (PASI score) before and after treatment with NB-UVB in comparison with MTX. Patients will be photographed at baseline and after 3 months of regular treatment by using high resolution digital camera canon EOS 1300D 18 megapixels (made in taiwan), photography will be done in standard light and distance.
Trial Locations
- Locations (1)
Aswan University - Faculty of Medicine
🇪🇬Aswan, Aswan Governorate, Egypt