NCT01325545已完成不适用
Detection of Occult Paroxysmal Atrial Fibrillation in Patients With Cryptogenic Stroke or TIA Using 21-Day Mobile Cardiac Outpatient Telemetry
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 132
- 主要终点
- Detection of Atrial Fibrillation
研究概览
简要总结
About one-third of patients with stroke have no documented cause for the cerebrovascular event (known as cryptogenic strokes). Atrial fibrillation is a common cause of stroke, but when transient (paroxysmal) it may remain undiagnosed. Recent data suggest that occult paroxysmal atrial fibrillation may be identified in patients with cryptogenic strokes using prolonged ambulatory cardiac rhythm monitors.
The investigators designed this study pursuing the following goals:
- To determine the prevalence of occult paroxysmal atrial fibrillation in patients with cryptogenic stroke using long-term mobile cardiac outpatient telemetry.
- To compare this prevalence to that found in a control group with stroke of known, non-cardioembolic cause.
- To look for clinical, laboratory, echocardiographic, and imaging data that serve as risk factors for occult paroxysmal atrial fibrillation in patients with cryptogenic stroke.
- To examine the utility of mobile cardiac outpatient telemetry, a relatively new diagnostic tool, in the evaluation of patients with cryptogenic stroke.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Stroke or TIA within previous 3 months
- •Stroke work up including: EKG, serum lipids, serum TSH, TTE or TEE, brain CT and/or MRI, Vascular Evaluation of head and neck using any combination of ultrasound, MRA, CTA, and conventional angiography
排除标准
- •Documented history of atrial fibrillation or flutter
- •PFO closure planned before conclusion of the monitoring period
- •Incomplete stroke work up
结局指标
主要结局
Detection of Atrial Fibrillation
时间窗: 21 days
Documented presence of atrial fibrillation detected by the monitoring device and independently confirmed by a board-certified cardiologist
次要结局
- Time to first episode of atrial fibrillation(Within monitoring period (3 weeks))
- Atrial Fibrillation Load(Within monitoring period (3 weeks))
- Adverse events related to mobile cardiac monitoring(21 days)
- Symptomatic status of episode of atrial fibrillation(21 days)
- Longest duration of episode of atrial fibrillation(21 days)
研究者
Alejandro Rabinstein
Professor of Neurology
Mayo Clinic
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