Spontaneous Spinal Cerebrospinal Fluid Leaks and Intracranial Hypotension
试验速览
- 阶段
- 不适用
- 状态
- 暂停
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Comparing the levels of prolactin pre and post treatment
研究概览
简要总结
Previous research has identified spontaneous cerebral spinal fluid leakage as a cause for spontaneous intracranial hypotension, leading to positional headache patterns. Typical magnetic resonance imaging findings include subdural fluid collections, enhancement of pachymenginges, engorgement of venous structures, pituitary hyperemia, and sagging of the brain (SEEPS). Because pituitary hyperemia has been documented in cases of spontaneous cerebral spinal fluid leakage and is known to mimic a pituitary tumor or hyperplasia, the investigators would like to like to assess the clinical manifestations and neuroimaging abnormalities of SIH patients with regard to the pituitary gland. Specifically, the investigators are looking to analyze the compression of the pituitary stalk and conduct a systemic evaluation of pituitary function in SIH patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female patients
- •Age 18 years and older
- •Diagnosis of SIH:
- •Brain MRI (SEEPS)
排除标准
- •Pregnant and post-partum females
- •Nursing mothers
- •Patients with potential hyperprolactinemia due to:
- •Hypothyroidism,
- •Chronic renal disorder
- •Liver disease (including cirrhosis)
- •Primary or secondary amenorrhea
- •Polycystic Ovary Syndrome
- •Seizure disorder
- •Illicit drug use
结局指标
主要结局
Comparing the levels of prolactin pre and post treatment
时间窗: 90 days
次要结局
未报告次要终点
研究者
Vivien Bonert, MD
Clinical Director, Pituitary Center
Cedars-Sinai Medical Center
