"Comparison of psychomotor recovery in patients receiving either intravenous propofol or dexmedetomidine infusions as part of balanced general anaesthesia: A prospective randomized single-blind study"
Trial Snapshot
- Phase
- Phase 4
- Status
- Not yet recruiting
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- compare the psychomotor recovery of patients receiving iv dexmedetomidine versus iv propofol infusion with Digit Symbol Substitution Test(DSST)[Annexure1] postoperatively
Study Overview
Brief Summary
Immediate post-operativerecovery forms a prerequisite for any successful anaesthetic procedure-especially so in day care surgeries. The DSST, primarily measures visual recording andincludes a motor component. It is an useful indicator of changes in sensoryprocessing performance induced by psychoactive tests.
There are only a few studies comparingpsychomotor effects of dexmedetomidine and propofol. We hypothesise that a goodDSST score indicates a better recovery from anaesthesia which can translate toan early discharge from a limited bed available Post Anaesthesia Care Unit(PACU) to postoperative ward. Therefore, we would like to compare the abovedrugs using DSST as a measure of psychomotor recovery surgeries under generalanaesthesia
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Participant Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 65.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •1.Patients with American Society of Anaesthesiologists physical status I, II, III aged 18 to 65 years.
- •2.Patients who are scheduled for surgeries under general anaesthesia.
- •3.Minimum duration of surgery lasting more than 120 minutes.
Exclusion Criteria
- •1.Patients unwilling to participate in the study.
- •2.Patients who are unable to give informed consent.
- •3.BMI>30kg/m
- •4.Patients with known history of psychiatric illness, chronic drug or alcohol abuse.
- •5.Patients with known hypersensitivity to drugs used.
- •6.Pregnant and lactating women.
- •Patients on concurrent sedative medications.
- •7.Patients who are unable to attempt or perform the DSST test.
Outcomes
Primary Outcomes
compare the psychomotor recovery of patients receiving iv dexmedetomidine versus iv propofol infusion with Digit Symbol Substitution Test(DSST)[Annexure1] postoperatively
Time Frame: 15 min, 30 min , 60 min , 90 min , 120 min
Secondary Outcomes
- i.To note the number of additional bolus doses of fentanyl and propofol given intraoperatively.(ii.To note the total amount of propofol and fentanyl consumed intraoperatively.)