"Comparison of psychomotor recovery in patients receiving either intravenous propofol or dexmedetomidine infusions as part of balanced general anaesthesia: A prospective randomized single-blind study"
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- compare the psychomotor recovery of patients receiving iv dexmedetomidine versus iv propofol infusion with Digit Symbol Substitution Test(DSST)[Annexure1] postoperatively
研究概览
简要总结
Immediate post-operativerecovery forms a prerequisite for any successful anaesthetic procedure-especially so in day care surgeries. The DSST, primarily measures visual recording andincludes a motor component. It is an useful indicator of changes in sensoryprocessing performance induced by psychoactive tests.
There are only a few studies comparingpsychomotor effects of dexmedetomidine and propofol. We hypothesise that a goodDSST score indicates a better recovery from anaesthesia which can translate toan early discharge from a limited bed available Post Anaesthesia Care Unit(PACU) to postoperative ward. Therefore, we would like to compare the abovedrugs using DSST as a measure of psychomotor recovery surgeries under generalanaesthesia
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients with American Society of Anaesthesiologists physical status I, II, III aged 18 to 65 years.
- •2.Patients who are scheduled for surgeries under general anaesthesia.
- •3.Minimum duration of surgery lasting more than 120 minutes.
排除标准
- •1.Patients unwilling to participate in the study.
- •2.Patients who are unable to give informed consent.
- •3.BMI>30kg/m
- •4.Patients with known history of psychiatric illness, chronic drug or alcohol abuse.
- •5.Patients with known hypersensitivity to drugs used.
- •6.Pregnant and lactating women.
- •Patients on concurrent sedative medications.
- •7.Patients who are unable to attempt or perform the DSST test.
结局指标
主要结局
compare the psychomotor recovery of patients receiving iv dexmedetomidine versus iv propofol infusion with Digit Symbol Substitution Test(DSST)[Annexure1] postoperatively
时间窗: 15 min, 30 min , 60 min , 90 min , 120 min
次要结局
- i.To note the number of additional bolus doses of fentanyl and propofol given intraoperatively.(ii.To note the total amount of propofol and fentanyl consumed intraoperatively.)