Automatization and defamiliarization in Obsessive Compulsive Disorder

Completed

Conditions: Obsessive Compulsive Disorder
obsessive neurosis
10002861

Registration Number: NL-OMON39479

Lead Sponsor: niversiteit Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 135

Inclusion Criteria

Patients will be included when they have a DSM-IV diagnosis of Obsessive Compulsive Disorder or another anxiety disorder diagnosis. Patients are allowed to use SSRI drugs, but not benzodiazepines because these have a negative effect on ones reaction speed.
Healthy controls will be age/education matched with the patients included in the study.

Exclusion Criteria

Subjects will be excluded from the study if they have color vision deficiency (color blindness); if they are insufficiently proficient in the Dutch language; if they are addicted to alcohol or drugs; if they are under 18 years of age; and/or if they present with symptoms from the psychotic spectrum. Patients who use benzodiazepine drugs will be excluded.
Healthy controls will also be excluded when they have any current psychiatric disorder.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are check duration at pre-test and post-test, and<br /><br>reaction times on the RIR task, as well as the measures at pre-test and<br /><br>post-test on the checking task, and the difference between pre- and post-test,<br /><br>in participants* ratings of memory vividness, memory detail and confidence in<br /><br>memory. The final three measures will be determined from VAS-scale indications. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>In order to test whether between-group differences are specifically related to<br /><br>OCD and not to patients being more anxious/depressed in general, we will<br /><br>measure depression (BDI), anxiety (BAI) and OCD (OCI-R and Y-BOCS) severity<br /><br>scores.<br /><br>Patients* medication will be recorded before the beginning of the experiment.<br /><br>While it is not expected that medication has an influence on the experimental<br /><br>results, recording the information leaves the option open to control for<br /><br>medication if need be. </p><br>