Sensory Symptoms in Tourette Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 214
- 试验地点
- 2
- 主要终点
- Baseline Sensory Perception Quotient score, short form
研究概览
简要总结
Patients with tics will be asked to complete a series of validated questionnaires (in electronic and/or paper format) regarding symptoms and conditions often associated with Tourette syndrome, including premonitory urges, sensory experiences, inattention, obsessive-compulsive tendencies, anxiety, and depression. Participants will also be asked to complete a quality of life assessment. This series of questionnaires will be administered annually.
详细描述
Patients with tics will be recruited to participate in an observational study assessing extent and variation in non-motor features of Tourette syndrome over time. Each participant will complete a battery of validated questionnaires and scales online or in paper format (per patient preference), including the Premonitory Urge to Tic Scale (PUTS), the Sensory Gating Inventory (SGI), the Sensory Perception Quotient, the ADHD Self-Report Screening Scale, and others. These questionnaires will be administered annually to patients. For the analysis, participants will be stratified by age into late adolescents (18-25 years old) and adults (older than 25 years) since adolescent development ends at approximately age 25.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years of age or older
- •Ability to provide informed consent and answer self-report questionnaires independently in English
- •Diagnosis of Tourette syndrome (TS), chronic motor tic disorder, or chronic vocal tic disorder
排除标准
- •History of psychotic disorder
- •History of significant neurologic disorder (e.g., stroke) other than TS or another chronic tic disorder
结局指标
主要结局
Baseline Sensory Perception Quotient score, short form
时间窗: Initial assessment at enrollment (time zero)
Validated instrument assessing anomalous sensory experiences. Scale consists of 35 items screening patients for hyper- or hypo-sensitivity to each of the sensory domains (touch, sight, sound, smell, and taste). Each scale item is a statement to which participants provide a ranking: 0 = strongly agree 1. = agree 2. = disagree 3. = strongly disagree The minimum score on the short from is 0; the maximum score is 140. Higher scores indicate more abnormal sensory experiences.
Change in Sensory Perception Quotient score, short form at 2 years
时间窗: 2 years
Validated instrument assessing anomalous sensory experiences. Scale consists of 35 items screening patients for hyper- or hypo-sensitivity to each of the sensory domains (touch, sight, sound, smell, and taste). Each scale item is a statement to which participants provide a ranking: 0 = strongly agree 1. = agree 2. = disagree 3. = strongly disagree The minimum score on the short from is 0; the maximum score is 140. Higher scores indicate more abnormal sensory experiences.
Change in Sensory Perception Quotient score, short form at 1 year
时间窗: 1 year
Validated instrument assessing anomalous sensory experiences. Scale consists of 35 items screening patients for hyper- or hypo-sensitivity to each of the sensory domains (touch, sight, sound, smell, and taste). Each scale item is a statement to which participants provide a ranking: 0 = strongly agree 1. = agree 2. = disagree 3. = strongly disagree The minimum score on the short from is 0; the maximum score is 140. Higher scores indicate more abnormal sensory experiences.
次要结局
- Baseline Premonitory Urge to Tic Scale score(Initial assessment at enrollment (time zero))
- Change in Premonitory Urge to Tic Scale score at 2 years(2 years)
- Change in Sensory Gating Inventory score at 1 year(1 year)
- Baseline Sensory Gating Inventory score(Initial assessment at enrollment (time zero))
- Change in Sensory Gating Inventory score at 2 years(2 years)
- Change in Premonitory Urge to Tic Scale score at 1 year(1 year)
研究者
David Isaacs
Associate Professor of Neurology
Vanderbilt University Medical Center