Sensory Symptoms in Tourette Syndrome and Obsessive-Compulsive Disorder
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Tourette Syndrome
- Sponsor
- Vanderbilt University Medical Center
- Enrollment
- 250
- Locations
- 1
- Primary Endpoint
- Sensory Gating Inventory
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
This study seeks to address two key questions related to sensory dysregulation in Tourette syndrome (TS) and obsessive compulsive disorder (OCD): 1) Is sensory dysregulation in OCD clinically distinct from that in TS? 2) To what extent does sensory dysregulation affect QOL in each of these disorders? Patients with TS, patients with OCD, and healthy controls will complete an online battery of validated questionnaires assessing sensory dysregulation, psychiatric symptoms, and quality of life.
Detailed Description
Tourette syndrome (TS) is a neurodevelopmental disorder affecting 1% of school-aged children, with one-third of patients suffering persistent tics into adulthood. Obsessive-compulsive disorder (OCD) is a common comorbidity with TS. Individuals with either TS or OCD frequently exhibit sensory dysregulation, manifesting as heightened awareness of internal and external stimuli. For patients with OCD, sensory dysregulation has been linked to obsessive-compulsive symptoms and is an important consideration in treatment strategies. Sensory dysregulation remains largely unexplored in TS, but preliminary data suggests it is dissociable from tics, linked with obsessive-compulsive symptoms, and associated with poorer quality of life (QOL). This study seeks to address two key questions related to sensory dysregulation in TS and OCD: 1) Is sensory dysregulation in OCD clinically distinct from that in TS? 2) To what extent does sensory dysregulation affect QOL in each of these disorders? To do so, we will recruit patients with TS, patients with OCD, and healthy controls to complete an online battery of validated questionnaires assessing sensory dysregulation, psychiatric symptoms, and QOL. Addressing these knowledge gaps will enhance our understanding of bothersome sensory symptoms in TS and OCD, shed light on clinical overlap and/or distinctions between these commonly co-occurring psychiatric diagnoses, and clarify QOL impact and the potential need for more direct targeting of these symptoms.
Investigators
David Isaacs
Assistant Professor of Neurology
Vanderbilt University Medical Center
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Sensory Gating Inventory
Time Frame: Day 1
36-item, validated self-report questionnaire assessing sensory gating symptoms, with score range 0-216. Higher scores indicate greater sensory gating impairment.
Secondary Outcomes
- Dimensional Obsessive Compulsive Scale(Day 1)
- Patient Health Questionnaire-9 Scale(Day 1)
- Generalized Anxiety Disorder-7 Scale(Day 1)
- Adult Attention Deficit Hyperactivity Disorder Self-Report Screening Scale(Day 1)
- Premonitory Urge to Tic Scale (for Tourette syndrome patients only)(Day 1)
- Adult Tic Questionnaire (for Tourette syndrome patients only)(Day 1)
- WHO Quality of Life - BREF(Day 1)