Acute Effect of Isometric Exercise on Blood Pressure in Hypertensive Patients

Not Applicable

• Conditions: Arterial Hypertension

• Registration Number: NCT03982758
• Lead Sponsor: Instituto de Cardiologia do Rio Grande do Sul

Brief Summary

International recommendations advocate dynamic or isometric strength training as an adjunct to aerobic exercise. Due to a lack of consensus, this research addresses the acute effects of isometric exercises by handgrip or lower limb isometry as a hypotensive strategy in hypertensive adults.

Detailed Description

This study is characterized as a randomized, controlled and blinded clinical trial for the evaluators and carried out integrally in the Laboratory of Clinical Investigation (LIC) of the Cardiology Institute of Rio Grande do Sul / University Foundation of Cardiology (ICFUC). The project follows all recommendations proposed by the CONSORT Statement.

The study will consist of individuals of both genders, aged between 40 and 70 years who have blood pressure above 120mmhg by 80mhg. The participants, after signing the informed consent, answered a questionnaire that will evaluate the habitual level of physical activity and will be submitted to isometric exercises of palmar grip or quadriceps muscle. Pre- and post-exercise blood pressure will be monitored through the ambulatory blood pressure monitoring (ABPM) method.

Study Timeline

• Study First Submitted: 2019-04-15
• Study First Submitted QC: 2019-06-07
• Study First Posted: 2019-06-12
• Study Start: 2019-12-09
• Status Verified: 2021-07
• Last Update Submitted: 2021-07-27
• Last Update Posted: 2021-07-28
• Primary Completion: 2022-03-18
• Study Completion: 2022-03-18

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Controlled hypertensive patients (use of medication) sedentary or physically inactive

Exclusion Criteria

• Pregnant women;
• Unstable angina;
• Class II, III or IV heart failure;
• Recent cardiovascular event (last 3 months);
• Chronic renal insufficiency;
• Diabetes;
• History of malignant diseases with life expectancy <2 years;
• Or Orthopedic limitations or any physical or mental limitation that impedes the performance of physical exercises.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
blood pressure	48 hours	Blood pressure will be evaluated by Ambulatory Blood Pressure Monitoring (ABPM) over 24h. For that, a Dyna-Map® branded instrument will be used, which will measure blood pressure on rest condition and another measure after the exercise session (totaling 48 horas), in all participants of the two study groups.

Trial Locations

Locations (1)

Instituto de Cardiologia/ fundação Universitária de Cardiologia; 🇧🇷 Porto Alegre, Rio Grande Do Sul, Brazil