Cardiovascular Response to Isometric Resistance Training in People With Hypertension for Blood Pressure Management
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Change in systolic and diastolic blood pressure
研究概览
简要总结
Recent meta-analyses suggest isometric resistance training (IRT) may be superior to aerobic exercise for lowering blood pressure. The investigators intend to conduct the largest, longest, prospective, double-blind randomized controlled trial using isometric resistance training to reduce blood pressure to reduce hypertension.
详细描述
We are looking to assess the effect of isometric exercise on ambulatory blood pressure in participants aged 40-70 years who are either pre- or mild hypertensive; either un-medicated or taking medication to control their blood pressure. Our secondary aims are to examine whether the size of blood pressure change is different in those people taking or not taking anti-hypertensive medication, to determine the anti-hypertensive mechanism to IRT, and to establish rate of de-training effects after participants have ceased IRT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Blood pressure above 120/80 currently not taking anti-hypertensive medications whose doctor has suggested would benefit from exercise; and
- •people currently taking beta blockers for blood pressure management.
排除标准
- •Younger than 30yrs and older than 70 yrs;
- •unable to voluntary participate;
- •unable to participate under doctor's recommendation;
- •arthritis or carpal tunnel which may be aggravated with handgrip exercise;
- •known cardiovascular disease (angina) and the following co-morbid conditions:
- •insulin resistance,
- •depression,
- •mobility impairment,
- •sleep apnoea,
- •fatty liver disease or
- •renal disease
结局指标
主要结局
Change in systolic and diastolic blood pressure
时间窗: Change measures: baseline and 12 weeks
次要结局
- Detraining effects, changes in systolic and diastolic blood pressure after cessation of Isometric Resistance Training(12 weeks and 24 weeks)
- Compare and contrast change in systolic and diastolic blood pressure of medicated and un-medicated participants(Baseline and 12 weeks)
研究者
Deb Carlson
Sponsor-Investigator
University of New England, Australia