Cardiac adaptation and recovery after preeclampsia
- Conditions
- preeclampsia100192801001027310038430
- Registration Number
- NL-OMON53038
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 1358
Cases consist of women (18 years or older) with preeclampsia (PE) in the
current pregnancy (PE is defined as hypertension (systolic blood pressure >= 140
mmHg and/or diastolic BP >= 90 mmHg) developed after 20 weeks of pregnancy with
de novo proteinuria (>= 300 mg/ 24 hours)), Controls are women (18 years or
older) with an uncomplicated pregnancy (i.e no foetal or maternal placental
complications, such as pregnancy induced hypertension, preeclampsia or
HELLP-syndrome, or small for gestational birth infancies)
Cases
* Women who do not want to be informed about the results of the tests, or women
who do not
want their general practitioner and specialist(s) to be informed about
the test results
* Known allergy for iodinated contrast (only if they chose to participate in a
track including
the CTA measurement)
* Known contraindication for the use of betablockers or nitroglycerine
Controls
* Women with diabetes Mellitus and gestational diabetes
* Women with (suspected) IUGR in the current pregnancy (estimated fetal weight
p<10)
* Preterm delivery of the current pregnancy ( gestational age <37 weeks)
* Women who do not want to be informed about the results of the tests, or women
who do not
want their general practitioner and specialist(s) to be informed about
the test results
* Known allergy for iodinated contrast (only if they chose to participate in a
track including
the CTA measurement)
* Known contraindication for the use of betablockers or nitroglycerine
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The pattern of cardiac recovery (in terms of cardiac geometry, function and<br /><br>miRNA expression) after a preeclamptic pregnancy compared to a normotensive<br /><br>pregnancy.<br /><br><br /><br>The relation between acute placental atherosis with subclinical coronary<br /><br>atherosclerosis at 12 months pospartum<br /><br>* </p><br>
- Secondary Outcome Measures
Name Time Method <p>Lifestyle (questionnaire)<br /><br>Blood Pressure<br /><br>Metabolic syndrome (MetS)<br /><br>Kidney function<br /><br>Glycocalyx thickness (by means of the Glycocheck)<br /><br>Coronary artery calcification (CAC)<br /><br>Carotid Intima media thickness<br /><br>Flow mediated dilation</p><br>