Cognitive Transfer Effects on Working Memory and Higher Cognitive Functions by Combined Attentional Filter Exercise and tDCS in Healthy Younger Adults
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Performance change in working memory and filtering performance
研究概览
简要总结
Investigation of how a single session of an attentional filter exercise of distractor inhibition combined with tDCS modulates cognitive functions like working memory, decision making and attentional control.
详细描述
The study is designed as a between subject design with two groups defined by real or sham tDCS. The distractor inhibition exercise is conducted under either sham or real tDCS. Cognitive performance is assessed pre and post tDCS application, complemented by a short-termed follow-up on a consecutive day. Interindividual working memory capacity at baseline is taken into consideration.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •right-handed
- •aged between 18 and 30 years
- •normal or corrected to normal vision
- •German-speaking
排除标准
- •dyschromatopsia
- •neurological or neuropsychiatric diseases
- •low seizure threshold
- •neurological medication
- •metal implants in the head
研究组 & 干预措施
tDCS group
one session of computerized change detection attentional filter exercise (selective attention) combined with real tDCS
干预措施: transcranial direct current stimulation (tDCS) (Device)
sham group
one session of computerized change detection attentional filter exercise (selective attention) combined with sham tDCS
干预措施: transcranial direct current stimulation (tDCS) (Device)
结局指标
主要结局
Performance change in working memory and filtering performance
时间窗: 30 minutes per pre-assessment, post assessment directly after intervention and short-termed follow-up on the consecutive day
Working memory and filtering performance (in % correct), effects of distractor interference for different set sizes
Reaction change in working memory and filtering performance
时间窗: 30 minutes per pre-assessment, post assessment directly after intervention and short-termed follow-up on the consecutive day
reaction times (in milliseconds), effects of distractor interference for different set sizes
Reaction change in computerized attentional filter exercise
时间窗: 45 minutes on 1st day (pre) and on consecutive day (post)
reaction times (in milliseconds), effects of distractor interference for different set sizes
Performance change in computerized attentional filter exercise
时间窗: 45 minutes on 1st day (pre) and on consecutive day (post)
attentional filtering performance (in % correct), effects of distractor interference for different set sizes
次要结局
- Spatial Span(10 minutes per pre-assessment and short-termed follow-up on the consecutive day)
- Daily Performance Questionnaires(5 minutes on first and consecutive day)
- Iowa Gambling Task(7 minutes per pre-assessment, post assessment directly after intervention and short-termed follow-up on the consecutive day)
- State-Anxiety(2 minutes on first and consecutive day)
- Daily Strategy Questionnaires(5 minutes on first and consecutive day)
- Trait-Anxiety(2 minutes on first day)
- Assessment of Sleep Quality(10 minutes on first and consecutive day)
研究者
Notger Müller
Prof. Dr. med. (Head of Neuroprotection Lab at the DZNE)
German Center for Neurodegenerative Diseases (DZNE)