A genetic study of left-handedness and language lateralization in extended pedigrees from a Dutch population isolate. An investigation of a possible endophenotype for psychosis
Completed
- Conditions
- decreased lateralizationleft-handedness1002930510039628
- Registration Number
- NL-OMON30043
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 600
Inclusion Criteria
1. All grandparents born in the Netherlands
2. Age minimal 14 years
3. left handed or right handed within a family with 3 or more left handed members.
Exclusion Criteria
1. age below 14 years
2. less than 3 left handed family members
3. not all grandparents born in the Netherlands
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1) co-segegration of left-handedness and decreased language lateralization 2)<br /><br>association of genomic candidate regions with left-handedness and decreased<br /><br>language lateralization 3) the association of identified candidate genes or<br /><br>genomic regions with left-handedness in an existing sample of schizophrenia<br /><br>patients and their association with schizophrenia in a case-control design. </p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>