The Characteristics and Role of Mucosal Microbiome After Treatment of Clostridioides Difficile Infection
Completed
- Conditions
- Clostridioides Difficile Infection
- Registration Number
- NCT04668014
- Lead Sponsor
- Mayo Clinic
- Brief Summary
This research is being done to study the ability of C. difficile to colonize the colonic mucosa of individuals with no prior history of C. difficile infection.
- Detailed Description
The ability of C. difficile to colonize the mucosa of the colon will be studied in healthy individuals with no history of C. difficile infection who are undergoing colonoscopy for colon cancer/polyp screening purposes.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- Adults aged 18 and over
- No history of C. difficile infection
- Undergoing clinically indicated colonoscopy for colon cancer screening or colon polyp surveillance purposes in the absence of active GI symptoms.
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Exclusion Criteria
- Known active pregnancy
- Other known active gastrointestinal infectious process
- Inflammatory gastrointestinal conditions (microscopic colitis, inflammatory bowel disease, Celiac disease)
- Vulnerable adults
- Any other disease(s), condition(s) or habit(s) that would interfere with completion of study, or in the judgment of the investigator would potentially interfere with compliance to this study or would adversely affect study outcomes
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Presence of C. difficile within the sigmoid colonic mucosal tissue 1 day (At time of biopsy) C. difficile identified on fluorescence microscopy via FISH staining
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Mayo Clinic in Rochester
🇺🇸Rochester, Minnesota, United States