NCT04668014已完成不适用
The Characteristics and Role of Mucosal Microbiome After Treatment of Clostridioides Difficile Infection
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Presence of C. difficile within the sigmoid colonic mucosal tissue
研究概览
简要总结
This research is being done to study the ability of C. difficile to colonize the colonic mucosa of individuals with no prior history of C. difficile infection.
详细描述
The ability of C. difficile to colonize the mucosa of the colon will be studied in healthy individuals with no history of C. difficile infection who are undergoing colonoscopy for colon cancer/polyp screening purposes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18 and over
- •No history of C. difficile infection
- •Undergoing clinically indicated colonoscopy for colon cancer screening or colon polyp surveillance purposes in the absence of active GI symptoms.
排除标准
- •Known active pregnancy
- •Other known active gastrointestinal infectious process
- •Inflammatory gastrointestinal conditions (microscopic colitis, inflammatory bowel disease, Celiac disease)
- •Vulnerable adults
- •Any other disease(s), condition(s) or habit(s) that would interfere with completion of study, or in the judgment of the investigator would potentially interfere with compliance to this study or would adversely affect study outcomes
结局指标
主要结局
Presence of C. difficile within the sigmoid colonic mucosal tissue
时间窗: 1 day (At time of biopsy)
C. difficile identified on fluorescence microscopy via FISH staining
次要结局
未报告次要终点
研究者
Purna C. Kashyap, MBBS
Principal Investigator
Mayo Clinic
研究点 (1)
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