EFFECTS OF CALIBRATED BLUE–YELLOW CHANGES IN LIGHT ON THE HUMAN CIRCADIAN CLOCK - A RANDOMISED CONTROLLED CLINICAL STUDY

Not Applicable

• Conditions: Healthy Volunteers

• Registration Number: DRKS00023603
• Lead Sponsor: FWF Wissenschaftsfonds

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-11-17
• Study Completion: 2022-12-23
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Age: 18-35 years
• Body Mass Index: 18.5-24.9 (i.e. normal weight according to WHO criteria)
• Informed consent as documented by signature of the participant

Exclusion Criteria

• Previous enrollment in the study’s project part
• Investigator’s family members, employees or other dependent persons
• Self-reported photosensitive epilepsy
• Pregnancy
• Chronic or debilitating medical conditions
• Drug use
• Abnormal colour vision as established in the Cambridge Colour Test
• Shift work < 3 months prior to beginning of the study
• Transmeridian travel (> 2 time zones) < 1 month prior to beginning of the study
• Extreme chronotype
• Short and long sleep duration (subjective sleep duration on workdays outside 6-10h according to the MCTQ)
• Inability to understand and/or follow procedures
• Non-adherence to sleep/wake times during the ambulatory part (i.e. protocol for the stabilization of the sleep-wake cycle

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Phase shift, i.e. difference in DLMO between the first evening of each experimental visit and the second evening.

Secondary Outcome Measures

Name	Time	Method
• The time course (t1, t2, …tn) of visual comfort ratings <br>• The time course (t1, t2, …tn) of median reaction time, 10% fastest reaction times, 10% slowest reaction times<br>• EEG-derived sleep onset latency<br>• EEG-redived slow wave activity (SWA) during the first sleep cycle