Vasodilation Effect of Inhalational Anesthetics

Not Applicable

Completed

• Conditions: General Anesthesia
• Interventions: Drug: Halothane; Drug: Isoflurane; Drug: Sevoflurane; Drug: Desflurane; Drug: Enflurane

• Registration Number: NCT00815269
• Lead Sponsor: Nanjing Medical University

Brief Summary

Previous studies on animals suggest that inhalational anesthetics can reduce vascular tension in vitro resulting in vasodilation and decrease in blood pressure. This role for inhalational anesthetics has essential clinical implications such as the condition of sepsis or septic shock or other shock-associated states during which the blood vessel constricts strongly and leads to circulation dysfunction. The vasodilation property of these anesthetics including halothane, isoflurane, sevoflurane, desflurane and enflurane enables them to be better options than other general anesthetics in many clinical conditions needing the vasculature to be dilated. The investigators hypothesized that these inhalational anesthetics can evoke vasodilation measured with ultrasonography during general anesthesia in vivo as the in vitro studies displayed.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-12
• Study First Submitted: 2008-12-26
• Study First Submitted QC: 2008-12-26
• Study First Posted: 2008-12-29
• Status Verified: 2009-12
• Primary Completion: 2009-12
• Study Completion: 2009-12
• Last Update Submitted: 2009-12-22
• Last Update Posted: 2009-12-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Must be undergoing general anesthesia
• Age between 19-45 years

Exclusion Criteria

• With hypertension
• Existing organic dysfunction
• Allergic to inhalant anesthetics
• Alcohol addictive or narcotic dependent patients
• A history of the use of centrally-acting drugs of any sort, chronic pain and psychiatric diseases records

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	Halothane	Halothane anesthesia: induction and maintenance with different doses
2	Isoflurane	Isoflurane anesthesia: induction and maintenance with different doses
3	Sevoflurane	Sevoflurane anesthesia: induction and maintenance with different doses
4	Desflurane	Desflurane anesthesia: induction and maintenance with different doses
5	Enflurane	Enflurane anesthesia: induction and maintenance with different doses

Primary Outcome Measures

Name	Time	Method
Ultrasonography of blood vessels including radial artery, brachial artery, femoral artery, popliteal artery	Ten min prior to anesthesia; 0 min of anesthesia; 0 min of the end of anesthesia induction; 5, 10, 20, 30, 60 min during maintenance of the anesthesia

Secondary Outcome Measures

Name	Time	Method
The time interval of between the initiation of the inhalational anesthetics delivered to the beginning of decreasing of blood pressure	From the beginning of anesthesia (0 min) till the first time of blood pressure decreased, this measure would be varied according to different individuals
The total dose of phenylephrine required to maintain baseline arterial blood pressure	From the beginning of anesthesia (0 min) to 20 min after anesthesia begun
Blood flow volume during anesthesia of the vasculature	Ten min prior to anesthesia; 0 min of anesthesia; 0 min of the end of anesthesia induction; 5, 10, 20, 30, 60 min during maintenance of the anesthesia
Blood pressure including systolic, diastolic and mean artery blood pressures	Ten min prior to anesthesia; 0 min of anesthesia; 0 min of the end of anesthesia induction; 5, 10, 20, 30, 60 min during maintenance of the anesthesia
Regression and correlation analyses between different doses of the anesthetics and the extent of vasodilation	Forty eight hours after operation

Trial Locations

Locations (1)

Nanjing Maternal and Child Health Care Hospital; 🇨🇳 Nanjing, Jiangsu, China