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SGS742 in Patients With Mild to Moderate Alzheimer's Disease (AD)

Phase 2
Completed
Conditions
Alzheimer's Disease
Registration Number
NCT00093951
Lead Sponsor
Saegis Pharmaceuticals
Brief Summary

The purpose of this trial is to determine the effect of a new drug, SGS742, on memory and cognition in patients with mild to moderate Alzheimer's disease.

Detailed Description

SGS742 is a GABA(B) receptor antagonist. It is an orally active drug and possesses neurochemical and psychopharmacologic features that suggest it could improve memory and cognition in humans. The primary objective of the SGS742 clinical trial will be to determine the effect of SGS742 on memory and cognition in individuals diagnosed with mild to moderate Alzheimer's disease. The duration of the study is 3 months with 5 clinic visits.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
280
Inclusion Criteria
  • 55 to 90 years of age
  • Diagnosed with mild to moderate Alzheimer's disease
  • Willing caregiver
  • In general good health
Exclusion Criteria
  • Call 1-877-MY-MEMORY and ask to be referred to a study center located near you for entry criteria information.

Prohibited Meds:

  • Alzheimer's medications (Aricept, Exelon, Remydl, Nemenda)

Study & Design

Study Type
INTERVENTIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (42)

Senior Adults Specialty Research, Inc.

🇺🇸

Austin, Texas, United States

National Clinical Research, Inc.

🇺🇸

Richmond, Virginia, United States

MetroHealth Medical Center

🇺🇸

Cleveland, Ohio, United States

Baystate Medical Center

🇺🇸

Springfield, Massachusetts, United States

Affiliated Research Institute

🇺🇸

San Diego, California, United States

Tukoi Institute for Clinical Research

🇺🇸

Miami, Florida, United States

Radiant Research San Antonio

🇺🇸

San Antonio, Texas, United States

Pacific Research Network, Inc.

🇺🇸

San Diego, California, United States

San Francisco Clinical Research Center

🇺🇸

San Francisco, California, United States

Lynn Health Science Institute

🇺🇸

Oklahoma City, Oklahoma, United States

Texas Medical Research Associates, LLC

🇺🇸

San Antonio, Texas, United States

The Mile High Research Center

🇺🇸

Denver, Colorado, United States

Psychopharmacology Research Association of Princeton, P.C.

🇺🇸

Princeton, New Jersey, United States

United Health Services Office of Clinical Trials

🇺🇸

Johnson City, New York, United States

Oregon Center for Clinical Investigations, Inc.

🇺🇸

Eugene, Oregon, United States

SW Medical Associates

🇺🇸

Las Vegas, Nevada, United States

University Memory and Aging Center

🇺🇸

Cleveland, Ohio, United States

RI Mood & Memory Research Institute

🇺🇸

E Providence, Rhode Island, United States

Claghorn-Lesem Research Clinic, Ltd.

🇺🇸

Bellaire, Texas, United States

Grayline Clinical Drug Trials

🇺🇸

Wichita Falls, Texas, United States

Dedicated Clinical Research

🇺🇸

Sun City, Arizona, United States

Clinical Trials Incorporated

🇺🇸

Little Rock, Arkansas, United States

Neuro Therapeutics, Inc.

🇺🇸

Pasadena, California, United States

Center for Neurologic Studies

🇺🇸

La Jolla, California, United States

Baumel-Eisner Neuromedical Institute, Inc.

🇺🇸

Boca Raton, Florida, United States

Research Center for Clinical Studies, Inc.

🇺🇸

Darien, Connecticut, United States

Southern California Clinical Research, Inc.

🇺🇸

San Marino, California, United States

Baumel-Eisner Neuromedical Institute

🇺🇸

Miami Beach, Florida, United States

Brain Matters, Inc.

🇺🇸

Delray Beach, Florida, United States

Allied Clinical Trials, The Neurology Group

🇺🇸

Miami, Florida, United States

DeKalb Neurology Associates, LLC

🇺🇸

Decatur, Georgia, United States

Ocala Neurodiagnostic Center

🇺🇸

Ocala, Florida, United States

CSI Research

🇺🇸

Decatur, Georgia, United States

MidAmerica Neuroscience Institute

🇺🇸

Lenexa, Kansas, United States

Neurology Department, LSU Health Sciences Center

🇺🇸

Shreveport, Louisiana, United States

Raleigh Neurology

🇺🇸

Raleigh, North Carolina, United States

Margolin Brain Institute

🇺🇸

Fresno, California, United States

NervePro Research

🇺🇸

Irvine, California, United States

Northwest NeuroSpecialists, PLLC

🇺🇸

Tucson, Arizona, United States

Bradenton Neurology, Inc.

🇺🇸

Bradenton, Florida, United States

Berma Research Group

🇺🇸

Hialeah, Florida, United States

The Clinical Trial Center, LLC

🇺🇸

Jenkintown, Pennsylvania, United States

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