Can unhelpful drinking memories be destabilised and weakened by ketamine in heavy drinkers?

Not Applicable

Completed

• Conditions: Hazardous and harmful drinking behaviour; Mental and Behavioural Disorders

• Registration Number: ISRCTN10138262
• Lead Sponsor: niversity College London

Brief Summary

2019 results in https://doi.org/10.1038/s41467-019-13162-w (added 27/11/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-11-01
• Study Start: 2019-02-18
• Last Update Posted: 6 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

1. Scoring >8 on the Alcohol Use Disorders Identification Test (AUDIT)
2. Consuming > 40 (men) or >30 (women) UK units/week
3. Primarily drinking beer
4. Non-treatment seeking
5. Drinking = 4 days/week
6. Drinking >3 units on drinking days
7. Aged 18-60
8. Endorsing a statement of being ‘highly motivated to reduce’ drinking
9. BMI >18<35

Exclusion Criteria

1. Diagnosis of alcohol or substance use disorder (AUD/SUD) or other psychiatric disorder
2. Undergoing or seeking treatment for alcohol use
3. Undergoing or seeking treatment for any psychiatric disorder
4. Use of recreational drugs (other than tobacco) > 1x/ month
5. Major physical health issues contraindicating ketamine
6. Blood pressure > 145/90, allergy/contraindication to ketamine
7. Pregnancy or breastfeeding

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Measured from baseline (pre-manipulation, Day 1) to post manipulation (Day 10):<br> 1. Alcohol reactivity and priming; operationalized as self-rated urge to drink in-vivo alcohol (beer), urge to drink more beer post-consumption and anticipated/actual enjoyment of the beer pre/post consumption.<br> 2. Harmful drinking behavior, operationalized as number of drinking days and heavy drinking or 'binge' days per week and quantitative alcohol consumption, as assessed by the Timeline Follow-Back.<br> 3. Perceived changes in drinking behaviour from Day 1 to Day 10, consisting of 5-point Likert scale items judging relative urge to drink, enjoyment of drinking and volume of drinking (anchored 'much less than usual' to 'much more than usual'). These are rated retrospectively on Day 10.<br>