Cognitive Function Analysis and qEEG Study in Long COVID-19 Syndrome Patients

Recruiting

• Conditions: Long COVID-19 Syndrome
• Interventions: Device: Quantitative Electroencephalography

• Registration Number: NCT05670418
• Lead Sponsor: Indonesia University

Brief Summary

Over than 30% individuals with COVID-19, including the asymptomatic ones, and around 80% of patients hospitalized with COVID-19 may experience post-COVID sequelae, which is commonly referred to as Long COVID Syndrome. This condition has ties to decreased cognitive function and may lead to neuropsychiatric disorders but still need to be studied further. Using a cross-sectional design, this study will analyze the relationship between cognitive function and neuropsychiatric disorders with brain wave activity in Long COVID patients.

The investigators conducted assessments utilizing the quantitative electroencephalogram (qEEG) measurement method and interviews using instruments such as the MOCA questionnaire and Self Rating Questionnaire (SRQ). With this qEEG examination, the investigators hoped that there will be an imbalance/abnormality of brain wave activity that arises related to impaired cognitive function.

Detailed Description

This study is aimed to analyze the cognitive function and neuropsychiatry disorders with brain wave activity using qEEG that occurs after COVID/Long Covid Syndrome.

The whole procedure will run for approximately 12 weeks based on the long COVID range.

The determinants of long COVID patients include: never been vaccinated, old age, comorbid, female population, and hospitalized patients.

The total number of subjects with the post-COVID syndrome in the proportion test is 30 subjects.

The measuring instruments used to measure the decline in cognitive function are the MOCA questionnaire and Self Rating Questionnaire (SRQ).

The target population is post-COVID-19 patients with Long COVID Syndrome.

The accessible population is post-COVID-19 patients who have been treated at RSCM Kiara and have regular checkups at the RSCM polyclinic with Long COVID Syndrome for 12 weeks or more.

The control population is post-COVID-19 patients who managed to recover without symptoms.

The Long COVID Syndrome patients who meet the inclusion criteria and have signed the consent.

Study Timeline

• Study Start: 2022-10-01
• Study First Submitted: 2022-11-22
• Study First Submitted QC: 2023-01-01
• Study First Posted: 2023-01-04
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-17
• Last Update Posted: 2023-11-18
• Primary Completion: 2023-12-30
• Study Completion: 2023-12-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

1. Post-COVID-19 patients with Long COVID-19 Syndrome
2. Over 18 years old
3. Willing to participate in the research
4. Completed the Montreal Cognitive Assessment (MoCA) and Self Rating Questionnaire (SRQ)

Exclusion Criteria

1. Patients with neuropsychiatric disorders before being infected with COVID-19

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
COVID-19	Quantitative Electroencephalography	Patients post-COVID-19 without Long COVID-19 Syndrome
Long COVID-19	Quantitative Electroencephalography	Patients post-COVID-19 with Long COVID-19 Syndrome

Primary Outcome Measures

Name	Time	Method
Cognitive Function	Through study completion, an average of 1 year	Cognitive Function will be assessed using the qEEG, with an abnormality of brain wave activity, it indicates impairment of cognitive function

Secondary Outcome Measures

Name	Time	Method
Cognitive quality Assessed by MOCA	Through study completion, an average of 1 year	Severe score: ≤10 Moderate score: 10-17 Mild score: 18-25 Normal score: 26-30
Self Rating Questionnaire (SRQ)	Through study completion, an average of 1 year	Lowest score: 0 Highest score: 20. Higher score indicates better health status.

Trial Locations

Locations (1)

Rumah Sakit Cipto Manunkusumo; 🇮🇩 Jakarta Pusat, DKI Jakarta, Indonesia