Particulate Air Pollution Exposure and Childhood Acute Respiratory Infections in Guatemala: A Randomized Intervention
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 537
- 试验地点
- 1
- 主要终点
- The primary outcome measure was physician-diagnosed pneumonia in children
研究概览
简要总结
The purpose of this study was to determine whether reduced exposure to indoor air pollution would reduce ALRI incidence in children <18 months of age. Households were randomized to receive a chimney stove (intervention group) or continue using an open fire for cooking and heating (control group).
详细描述
Acute lower respiratory infections (ALRI) are the chief killer of children. Most cases are pneumonia and the majority occur among poor children under five years in developing countries. Poverty might be said to be the primary cause, which manifests as malnutrition, including micro-nutrient deficiencies, and lack of access to medical care. Another attribute of poverty is household indoor air pollution (HAP) from use of unprocessed solid fuels such as biomass (wood, animal dung and crop wastes) and coal in simple stoves. A meta-analysis of published observational studies found that young children exposed to smoke from household solid fuel use had a rate of ALRI twice that of children not exposed or where clean fuels were used. Recent studies have shown similar ALRI risks associated with short-term air pollution measurements and other indicators of exposure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- — 至 18 Months（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Households were invited to participate in the study if they met the following inclusion criteria:
- •Used only an open fire for cooking and heating
- •Had a pregnant woman or child < 4 months residing in the home
- •Identified as Mam (the regional ethnic group), and had
- •Minimal summer migration (less than 12 weeks per year)
排除标准
- •Households were excluded from participating if:
- •The household was already using a chimney stove for cooking
- •There was no child <4 months of age or a pregnant woman residing in the home
- •Seasonal migration required the family to move to another region for more than 12 weeks of the year
结局指标
主要结局
The primary outcome measure was physician-diagnosed pneumonia in children
时间窗: Through 18 months of age
次要结局
- Severe (hypoxaemic) and RSV pneumonia(Through 18 months of age)