The effect of delta-9-tetrahydrocannabivarin (THCV) on delta-9-tetrahydrocannabinol (THC)
Not Applicable
Completed
- Conditions
- Cannabis elicited psychopathology and cognitive impairmentMental and Behavioural DisordersMental and behavioural disorders due to use of cannabinoids
- Registration Number
- ISRCTN93423464
- Lead Sponsor
- King's College London (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Male
- Target Recruitment
- 10
Inclusion Criteria
Healthy male volunteers aged 21-35 who have used cannabis not more than 25 times
Exclusion Criteria
1. History (or family history) of mental illness (including any psychotic disorder, depression/anxiety)
2. Major physical illness,
3. Previous treatment with psychotropic medicines and drug/alcohol addiction
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Scores on the following cognitive tasks:<br>1. The Hopkins Verbal Learning Task<br>2. Digit-span <br>3. The time estimation task<br><br>Psychotic symptoms:<br>1. The Community Assessment of Psychic Experiences (CAPE) scale<br>2. The Self Assessment Module (SAM) scale<br><br>Measures will be taken at baseline, post THCV/placebo and post THC over the course of 5 days
- Secondary Outcome Measures
Name Time Method Scores on the following scales of psychopathology:<br>1. The Mood Adjective Check List <br>2. Beck?s Anxiety Inventory<br>3. Visual Analogue Scales<br>4. The State Social Paranoia Scale<br><br>Measures will be taken at baseline, post THCV/placebo and post THC over the course of 5 days