How do adverse childhood experiences and psychiatric disorders impact social cognition?

• Conditions: DSM-IV 309.81 Posttraumatic Stress Disorder, DSM-IV 296.2x/296.3x Major Depressive Disorder, DSM-5 300.82 Somatic Symptom Disorder; F43.1; F32.0; F32.1; F32.2; F33.0; F33.1; F33.2; Post-traumatic stress disorder; Mild depressive episode

• Registration Number: DRKS00015182
• Lead Sponsor: Klinik für Allgemeine Psychiatrie, Zentrum für Psychosoziale Medizin der Universität Heidelberg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-07-26
• Study Completion: 2022-05-09
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 183

Inclusion Criteria

for patients:
- posttraumatic stress disorder, somatic symptom disorder or major depression as first lifetime and still current diagnosis
for healthy controls:
- no current and no past psychiatric Axis-I disorder

Exclusion Criteria

for patients
- unable to consent - pregnancy - psychotropic medication with the exception of regular medication with antidepressants, antipsychotics for sleep-induction, and pregabalin - current/past bipolar I disorder or schizophrenia - current/ past epilepsy - known brain traumata, brain tumor or other significant neurological/ medical factors - substance addiction during the last two years prior to study admission - current substance abuse - left handedness
for all healthy controls
- unable to consent - pregnancy - psychotropic medication - current/ past epilepsy - known brain traumata, brain tumor or other significant neurological/ medical factors - substance addiction during the last two years prior to study admission - current substance abuse - left handedness
Further exclusion criterion for healthy controls without adverse childhood experiences
- above-threshold scores of adverse childhood experiences as established by a validated instrument measuring adverse childhood experiences

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Interaction effect (intensity of adverse childhood experiences x functional domain): Patients and healthy controls with high intensity of adverse childhood experiences show a threat hypersensitivity, a diminished reward sensitivity and a reduced theory of mind capacity compared to patients and healthy controls with low intensity of adverse childhood experiences.<br>Measurements will be taken on one day.

Secondary Outcome Measures

Name	Time	Method
cardiac interoception capacity, measured with the subjectively counted heart beats and the electrocardiographic activity.<br>Measurements will be taken on the same day as the primary outcomes are measured.