VDR and TFIP11 Gene Polymorphism and Gene-environmental Interaction in Adults

Completed

• Conditions: Low Caries Experience; High Caries Experience
• Interventions: Genetic: high caries experience

• Registration Number: NCT04124718
• Lead Sponsor: Recep Tayyip Erdogan University Training and Research Hospital

Brief Summary

VDR and TFIP11 Gene polymorphism and gene-environment interactions on caries etiology and susceptibility in adults.

Detailed Description

To date, genes can be grouped into categories based on the factor influencing dental caries. The major candidate gene categories to date include enamel formation genes, immune response genes, genes related to saliva, and genes related to taste and dietary habits.

TFIP11 and VDR genes are related to enamel formation genes

Study Timeline

• Study First Submitted: 2019-10-10
• Study First Submitted QC: 2019-10-10
• Study First Posted: 2019-10-11
• Study Start: 2019-12-26
• Primary Completion: 2020-01-26
• Study Completion: 2020-02-10
• Status Verified: 2021-04
• Last Update Submitted: 2021-04-12
• Last Update Posted: 2021-04-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

• adult be between 24 and 40 years old
• subject has DMFT (Decayed, Missing, Filled, Permanent Tooth) DMFT≤4 , or, DMFT>13.9

Exclusion Criteria

• systemic or genetic disorders
• orthodontic appliances
• pregnant women

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
high caries experience	high caries experience	80 adults will be allowed in the high caries experience group according to DMFT index DMFT\>13.9
low caries experience	high caries experience	80 adults will be allowed in the high caries experience group according toDMFT index DMFT≤4

Primary Outcome Measures

Name	Time	Method
past caries experience	3 weeks	Each tooth will be examined and recorded as decayed, missing, or filled

Secondary Outcome Measures

Name	Time	Method
Plaque index	3 weeks	The plaque amount is scored by using Silness\&Löe Plaque Index plaque index PI\<1.0 healthy PI 1.1-2.0 mild PI\>2 high plaque

Trial Locations

Locations (1)

Recep Tayyip Erdogan University Dentistry Faculty; 🇹🇷 Rize, Turkey